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* Jin M, Li S, Moghrabi WN, Sun H, Travis GH. ''Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium.'' Cell. 2005 [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed Article]. |
* Jin M, Li S, Moghrabi WN, Sun H, Travis GH. ''Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium.'' Cell. 2005 [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?CMD=search&DB=pubmed Article]. |
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[[Category:Vision]] |
[[Category:Vision]] |
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[[Category:Sensory receptors]] |
[[Category:Sensory receptors]] |
Revision as of 16:51, 10 April 2007
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The visual cycle refers to the conversion of a photon into an action potential in the retina. This process occurs via G-protein coupled receptors called opsins which contain the chromophore 11-cis retinal. 11-cis retinal is covalently linked to the opsin receptor via a schiff base forming a retinylidene protein. When struck by a photon, 11-cis retinal undergoes photoisomerization to all-trans retinal which changes the conformation of the opsin GPCR leading to signal transduction cascades which ultimately causes an action potential which results in visual perception.
Following isomerization and release from the opsin protein, all-trans retinal is reduced to all-trans retinol and travels back to the retinal pigment epithelium to be "recharged". It is first esterified by lecithin-retinol acyltransferase (LRAT) and then converted to 11-cis retinol by the isomerohydrolase RPE65. Finally, it is oxidized to 11-cis retinal before traveling back to the rod outer segment where it can again be conjugated to an opsin to form a new, functional visual pigment (rhodopsin).
References
- Moiseyev G, Chen Y, Takahashi Y, Wu BX, Ma JX. RPE65 is the isomerohydrolase in the retinoid visual cycle. Proc. Nat. Acad. Sci. 2005 Article.
- Jin M, Li S, Moghrabi WN, Sun H, Travis GH. Rpe65 is the retinoid isomerase in bovine retinal pigment epithelium. Cell. 2005 Article.
Metabolism map | ||||||
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Glucuronate metabolism Pentose interconversion Inositol metabolism Cellulose and sucrose metabolism Starch and glycogen metabolism Other sugar metabolism Amino sugars metabolism Small amino acid synthesis Branched amino acid synthesis Purine biosynthesis Histidine metabolism Aromatic amino acid synthesis Anaerobic respiration Aspartate amino acid group synthesis Porphyrins and corrinoids metabolism Glutamate amino acid group synthesis Pyrimidine biosynthesis
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