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Vinblastine chemical structure
|ATC code |
|Molecular weight||810.974 g/mol|
|Elimination half-life||24.8 hours (terminal)|
|Excretion||Biliary and renal|
|Routes of administration||Exclusively intravenous|
Vinblastine is an anti-mitotic drug used as an antineoplastic drug to treat certain kinds of cancer, including Hodgkin's lymphoma, non-small cell lung cancer, breast cancer, head and neck cancer, and testicular cancer.
History[edit | edit source]
Vinblastine was first isolated by Robert Noble and Charles Thomas Beer from the Madagascar periwinkle plant. Vinblastine's utility as a chemotherapeutic agent was first discovered when it was crushed into a tea. Consumption of the tea led to a decreased number of white blood cells; therefore, it was hypothesized that vinblastine might be effective against cancers of the white blood cells such as lymphoma.
Pharmacology[edit | edit source]
Vinblastine is a vinca alkaloid and a chemical analogue of vincristine. It binds tubulin, thereby inhibiting the assembly of microtubules. It is M phase cell cycle specific since microtubules are a component of the mitotic spindle and the kinetochore which are necessary for the separation of chromosomes during anaphase of mitosis. Toxicities include bone marrow suppression (which is dose-limiting), gastrointestinal toxicity, potent vesicant (blister-forming) activity, and extravasation injury (forms deep ulcers).
Vinblastine paracrystals may be composed of tightly-packed unpolymerized tubulin or microtubules.
Indications[edit | edit source]
Vinblastine is a component of a number of chemotherapy regimens, including ABVD for Hodgkin lymphoma. It is also used to treat histiocytosis according to the established protocols of the Histiocytosis Association of America.
See also[edit | edit source]
Footnotes[edit | edit source]
- Starling D (Jan 1976). Two ultrastructurally distinct tubulin paracrystals induced in sea-urchin eggs by vinblastine sulphate.. J Cell Sci 20 (1): 79–89.
References[edit | edit source]
- Bell, G. A., & Morgan, I. G. (1981). The effects of colchicine and vinblastine on memory in chicks: Behavioural Brain Research Vol 2(3) May 1981, 301-322.
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