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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
solute carrier family 18 (vesicular monoamine), member 1 | |
---|---|
Symbol(s): | SLC18A1 VMAT1, VAT1 |
Locus: | 8 p21.3 |
EC number | [1] |
EntrezGene | 6570 |
OMIM | 193002 |
RefSeq | NM_003053 |
UniProt | P54219 |
solute carrier family 18 (vesicular monoamine), member 2 | |
---|---|
Symbol(s): | SLC18A2 VMAT2 |
Locus: | 10 q25 |
EC number | [2] |
EntrezGene | 6571 |
OMIM | 193001 |
RefSeq | NM_003054 |
UniProt | Q05940 |
The vesicular monoamine transporter is a transport protein located within the presynaptic cell. It comprises the two isoforms VMAT1 and VMAT2.
VMAT2[]
Impairment and Dysfunction[]
Cocaine users display a marked reduction in VMAT2 immunoreactivity. Suffers of cocaine-induced mood disorders displayed a significant loss of VMAT2 immunoreactivity, this might reflect damage to striatal dopamine fibers. These neuronal changes could play a role in causing disordered mood and motivational processes in more severely addicted users.[1]
Binding Sites and Ligands[]
One binding site is that of DTBZ. Lobeline binds at this site. At a distinct site dextroamphetamine binds. Its activity at VMAT2 is a crucial part of its monoamine releasing action.
References[]
Further reading[]
- Kilbourne, M.R. (1997) In Vivo Radiotracers for Vesicular Neurotransmitter Transporters. Nuclear Medicine & Biology, Vol.24, pp.615-619.
- Weihe, E. and Eiden, L.E. (2000) Chemical neuroanatomy of the vesicular amine transporter. FASEB J, Vol.14, pp.2435-2449.
External links[]
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