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vasoactive intestinal peptide receptor 1
Symbol(s): VIPR1 RDC1, HVR1, VAPC1
Locus: 3 p22
EC number [1]
EntrezGene 7433
OMIM 192321
RefSeq NM_004624
UniProt P32241
vasoactive intestinal peptide receptor 2
Symbol(s): VIPR2 VPAC2
Locus: 7 q36.3
EC number [2]
EntrezGene 7434
OMIM 601970
RefSeq NM_003382
UniProt P41587
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
Locus: 7 p14
EC number [3]
EntrezGene 117
OMIM 102981
RefSeq NM_001118
UniProt P41586

There are two known receptors for the vasoactive intestinal peptide (VIP) termed VPAC1 and VPAC2.[1][2] These receptors bind both VIP and pituitary adenylate cyclase-activating polypeptide to some degree. Both receptors are members of the 7 transmembrane g protein-coupled family of receptors.

VPAC1 is distributed widely in the CNS, liver, lung, intestine and T-lymphocytes.

VPAC2 is found in the CNS, pancreas, skeletal muscle, heart, kidney, adipose tissue, testis, and stomach.

References[edit | edit source]

  1. Laburthe M, Couvineau A, Marie JC (2002). VPAC receptors for VIP and PACAP. Recept. Channels 8 (3-4): 137–53.
  2. Laburthe M, Couvineau A (2002). Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP. Regul. Pept. 108 (2-3): 165–73.

External links[edit | edit source]

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