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vasoactive intestinal peptide receptor 1
Symbol(s): VIPR1 RDC1, HVR1, VAPC1
Locus: 3 p22
EC number [1]
EntrezGene 7433
OMIM 192321
RefSeq NM_004624
UniProt P32241
vasoactive intestinal peptide receptor 2
Symbol(s): VIPR2 VPAC2
Locus: 7 q36.3
EC number [2]
EntrezGene 7434
OMIM 601970
RefSeq NM_003382
UniProt P41587
adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
Locus: 7 p14
EC number [3]
EntrezGene 117
OMIM 102981
RefSeq NM_001118
UniProt P41586

There are two known receptors for the vasoactive intestinal peptide (VIP) termed VPAC1 and VPAC2.[1][2] These receptors bind both VIP and pituitary adenylate cyclase-activating polypeptide to some degree. Both receptors are members of the 7 transmembrane g protein-coupled family of receptors.

VPAC1 is distributed widely in the CNS, liver, lung, intestine and T-lymphocytes.

VPAC2 is found in the CNS, pancreas, skeletal muscle, heart, kidney, adipose tissue, testis, and stomach.


  1. Laburthe M, Couvineau A, Marie JC (2002). VPAC receptors for VIP and PACAP. Recept. Channels 8 (3-4): 137–53.
  2. Laburthe M, Couvineau A (2002). Molecular pharmacology and structure of VPAC Receptors for VIP and PACAP. Regul. Pept. 108 (2-3): 165–73.

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