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The thiomersal controversy describes claims that vaccines containing the mercury-based preservative thiomersal contribute to the development of autism and other brain development disorders. The current scientific consensus is that no convincing scientific evidence supports these claims.
Thiomersal, also spelled thimerosal, is an organomercury compound used as a preservative in vaccines since the 1930s to prevent bacterial and fungal contamination. In July 1999, following a review of mercury-containing food and drugs, the Centers for Disease Control (CDC) and the American Academy of Pediatrics (AAP) asked vaccine makers to remove thiomersal from vaccines as quickly as possible, and it was rapidly phased out of most U.S. and European vaccines. This action was based on the precautionary principle, which assumes that there is no harm in exercising caution even if it later turns out to be unwarranted. However, the removal of thiomersal coincided with statements from scientific bodies indicating that it was harmless, sparking confusion and controversy that has diverted attention and resources away from other efforts to find the causes of autism. Thousands of lawsuits have been filed in the U.S. to seek damages from alleged toxicity from vaccines, including those purportedly caused by thiomersal.
The scientific consensus—including scientific and medical bodies such as the Institute of Medicine and World Health Organization as well as governmental agencies such as the Food and Drug Administration and the CDC—rejects any role for thiomersal in autism or other neurodevelopmental disorders. Multiple lines of scientific evidence have been cited to support this conclusion: for example, the clinical symptoms of mercury poisoning differ significantly from those of autism. Most conclusively, eight major studies (as of 2008) examined the effect of reductions or removal of thiomersal from vaccines. All eight demonstrated that autism rates failed to decline despite removal of thiomersal, arguing strongly against a causative role.
Background of controversy[edit | edit source]
Scientific background[edit | edit source]
After the FDA Modernization Act of 1997 mandated a review and risk assessment of all mercury-containing food and drugs, vaccine manufacturers responded to FDA requests to provide detailed information about the thimerosal content of their preparations in December 1998 and April 1999. Upon conclusion of this review, the FDA, in conjunction with the other members of the US Public Health Service (USPHS), the National Institutes of Health (NIH), CDC and Health Resources and Services Administration (HRSA) in a joint statement with the American Academy of Pediatrics (AAP), concluded:
"Our review revealed no evidence of harm caused by doses of thimerosal found in vaccines, except for local hypersensitivity reactions. At the time of our review, vaccines containing thimerosal as a preservative could expose infants to cumulative mercury at levels that exceed EPA recommendations during the first 6 months of life. The clinical significance of this conclusion is not currently known; EPA guidelines contain as much as a 10-fold safety factor and such guidelines are meant to be starting points for the evaluation of mercury exposure. However, reducing exposure to thimerosal from vaccines is merited given the goal of reducing human exposure to mercury from all sources, the feasibility of removing thimerosal as a vaccine preservative, and the desirability of ensuring public confidence in the safety of vaccines."
The FDA noted that while the vaccination schedule at that time might have exceeded EPA standards for mercury exposure during the first 6 months of life, it did not exceed those of the FDA, Agency for Toxic Substances and Disease Registry (ATSDR), or WHO. The FDA also noted some difficulty interpreting toxicity of the ethylmercury in thiomersal because guidelines for mercury toxicity were based primarily on studies of methylmercury. Despite the lack of convincing evidence of toxicity of thiomersal, the USPHS and AAP determined that thiomersal should be removed from vaccines as a purely preventative measure and to increase public confidence in vaccines.
Due to continued public concern, the Centers for Disease Control and the National Institutes of Health (NIH) asked the National Academy of Science's (NAS) Institute of Medicine (IOM) to establish an independent expert committee to review hypotheses about existing and emerging immunization safety concerns. In 2001 the committee reported:
"The committee concludes that although the hypothesis that exposure to thimerosal-containing vaccines could be associated with neurodevelopmental disorders is not established and rests on indirect and incomplete information, primarily from analogies with methylmercury and levels of maximum mercury exposure from vaccines given in children, the hypothesis is biologically plausible. The committee also concludes that the evidence is inadequate to accept or reject a causal relationship between thimerosal exposures from childhood vaccines and the neurodevelopmental disorders of autism, ADHD, and speech or language delay."
Social and political background[edit | edit source]
The FDA actions prompted autism advocates to consider the possibility of thiomersal as a cause of autism. The indirect evidence included analogy with neurotoxic effects of mercury compounds, extrapolation from laboratory and animal studies, and comparisons between trends in vaccination and autism cases.
This concept also gained support in the political sphere, with Rep. Dan Burton and Rep. David Weldon openly supporting this movement as well. A number of hearings were held in the Subcommittee on Human Rights and Wellness, Committee on Government Reform, chaired by Rep. Burton, on the topic of autism and vaccines. His staff concluded:
"Thimerosal used as a preservative in vaccines in [sic] likely related to the autism epidemic. This epidemic in all probability may have been prevented or curtailed had the FDA not been asleep at the switch regarding the lack of safety data regarding injected thimerosal and the sharp rise of infant exposure to this known neurotoxin. Our public health agencies’ failure to act is indicative of institutional malfeasance for self-protection and misplaced protectionism of the pharmaceutical industry"
Rationale for concern[edit | edit source]
Supporters of a link between thiomersal and autism cite several lines of reasoning for their concerns, including:
- Appeal for caution: precise thresholds for ethylmercury toxicity have not been fully studied, and methylmercury is a poor surrogate for studying the toxicity of thiomersal.
- In vitro tests: cultured cells in laboratory show adverse effects when exposed to ethylmercury.
- An in vivo study reported in 2004 that autoimmune disease-sensitive mice exposed to thiomersal had growth delay, reduced locomotion, exaggerated response to new stimuli, and uncommon neuronal structure in some brain areas. The exposure attempted to replicate the one-year schedule for U.S. infants in 2001, adjusted for weight and age. However, these results could not be replicated; a 2007 study by another group using the same mouse strain found no pervasive developmental neurotoxicity. Also, a 2008 study reported that male rats are more susceptible to thiomersal poisoning than female.
- Unscientific reports that autism is rarer in the Amish community and other non-vaccinated groups. The reports are undercut by the fact that Amish genes may differ from those in the general community, that people in the Amish community have low exposures to many other potential hazards (for example, pesticides and plastics) and that increasingly, the Amish do receive at least some vaccinations.
- Epidemiologic data: a series of epidemiologic studies coauthored by Mark Geier claimed a population-level correlation between thiomersal and autism. An article in the journal Pediatrics found these epidemiologic studies to suffer from numerous fundamental methodological flaws which bias and invalidate their claims. The dramatic increase in reported cases of autism during the 1990s and early 2000s is largely attributable to changes in diagnostic practices, referral patterns, availability of services, age at diagnosis, and public awareness; it is unknown whether autism's true prevalence increased during the period.
- Concern that mercury might have synergistic effects with other metals and toxicants.
Despite the 1999 recommendation by the USPSH and AAP, some vaccines continue to contain non-trace amounts of thiomersal, mainly in vaccines targeted against influenza and tetanus. Other products that may contain thimerosal include products derived from blood plasma such as Rho(D) Immune Globulin, pit viper antivenin and coral snake antivenin, as well as black widow spider antivenin.
Scientific consensus on controversy[edit | edit source]
The scientific consensus is reflected in another committee report commissioned by the CDC by the Institute of Medicine that follows up on the initial 2001 report. Since the 2001 report, the IOM committee took into account new data that had been published in the interim, including a number of large scale epidemiologic studies focusing on the relationship between thiomersal and autism in a number of countries including the US, Sweden, Denmark, and the UK.
The committee noted, in response to those who cite in vitro or animal models as evidence for the link between autism and thiomersal:
"However, the experiments showing effects of thimerosal on biochemical pathways in cell culture systems and showing abnormalities in the immune system or metal metabolism in people with autism are provocative; the autism research community should consider the appropriate composition of the autism research portfolio with some of these new findings in mind. However, these experiments do not provide evidence of a relationship between vaccines or thimerosal and autism. In the absence of experimental or human evidence that vaccination (either the MMR vaccine or the preservative thimerosal) affects metabolic, developmental, immune, or other physiological or molecular mechanisms that are causally related to the development of autism, the committee concludes that the hypotheses generated to date are theoretical only."
Based on an exhaustive review of the scientific literature, the committee concludes:
"Thus, based on this body of evidence, the committee concludes that the evidence favors rejection of a causal relationship between thimerosal-containing vaccines and autism." [bold in original]
This committee felt so strongly about this conclusion that they state:
"The committee concludes that much more research must be conducted on autism. However, research should be directed towards those lines of inquiry most supported by the current state of knowledge. The vaccine hypotheses are not currently supported by the evidence."
Three large-scale controlled observational studies have been reported on this issue; none have found an association between thiomersal-containing vaccines (TCVs) and autism. A study from Denmark noted no decrease in autism rates despite cessation of TCVs and a UK study found that TCVs actually had a protective effect with respect to autism. Because the Danish and UK studies involved only diphtheria-tetanus-pertussis (DTP) or diphtheria-tetanus (DT) vaccines, they are less relevant for the higher thiomersal exposure levels that occurred in the U.S. For the U.S., a study based on the Vaccine Safety Datalink found no association between TCVs and autism. Some smaller studies have also found no association between TCVs and autism and a study found no association between thimerosal and the neurological signs of autism. Another smaller study also found a protective effect: it reported a significantly lower prevalence of autism spectrum disorders among children exposed to thimerosal (5.95 per 1,000 versus 8.27 per 1,000).
The research of Mark Geier, the main source of epidemiologic data used by supporters of a link between thiomersal and autism, has received considerable criticism, including charges of not presenting methods and statistical analyses to others for verification, improperly analyzing data taken from Vaccine Adverse Event Reporting System, as well as either mislabelling or confusing fundamental statistical terms in his papers.
Further evidence of the position of the scientific consensus includes the rejection of a causal link between thimerosal and autism by the main scientific and medical professional bodies including the American Medical Association, the American Academy of Pediatrics, the American College of Medical Toxicology, the Canadian Paediatric Society, the National Academy of Sciences, the Food and Drug Administration, Centers for Disease Control and Prevention, the World Health Organization, the Public Health Agency of Canada, and the European Medicines Agency.
Effects of the controversy[edit | edit source]
In July 1999 the CDC and the AAP asked vaccine makers to remove thiomersal from vaccines as quickly as possible, and asked doctors to delay the birth dose of hepatitis B vaccine in children not at risk for hepatitis. The CDC and the AAP followed the precautionary principle, which assumes that there is no harm in exercising caution even if it later turns out to be unwarranted, but their action sparked confusion, controversy and some harm. About 10% of hospitals suspended the use of hepatitis B vaccine for all newborns, and one child born to a Michigan mother infected with hepatitis B virus died of it.
The notion that thiomersal causes autism has led some parents to have their children treated with chelation therapy; about 10,000 autistic children in the U.S. receive mercury-chelating agents every year, and in August 2005 a 5-year-old autistic boy died from an arrhythmia caused by injection of the chelating agent EDTA.
The notion has also diverted attention and resources away from efforts to determine the causes of autism. Alison Singer, a senior executive of Autism Speaks, resigned from the group in 2009 in a dispute over whether to fund more research on links between vaccination and autism, saying, "There isn't an unlimited pot of money, and every dollar spent looking where we know the answer isn't is one less dollar we have to spend where we might find new answers."
Court cases[edit | edit source]
- Further information: Vaccine court
From 1988 until 1 January 2008, 5,263 claims relating to autism were made to the U.S. court that oversees compensation. One claim was compensated, and 350 were dismissed; the rest are pending. In the one autism-related case, the government conceded that the child had a pre-existing mitochondrial disorder with autism-like symptoms aggravated by simultaneous immunizations against nine diseases, two of which contained thiomersal.
Timeline[edit | edit source]
- 1930s - first added to vaccines and other products as a bactericide.
- Mid-1980s - used as a preservative in virtually all whole-cell DPT vaccines, which were routinely administered four times each to children before eighteen months of age, starting at two months.
- Late 1980s - Hib vaccines are recommended for administration to children at eighteen months. They contain thiomersal.
- Early 1990s - In the USA three doses of Hepatititis B vaccine (at that time containing Thiomersal) are recommended for infants under six months of age, beginning on the day of birth; four doses of Hib are recommended within an eighteen month period, beginning at age two.
- Late 1990s - three of the vaccines included in Vaccination schedules for children between six and eighteen months of age contain thiomersal.
- 1999 - The American Academy of Pediatrics requests removal of thiomersal from all pediatric vaccines.
- 2001 - Thiomersal is no longer used in routine childhood vaccines in the U.S.
- 2001 - The Institute of Medicine, citing insufficient evidence, is unable to prove or disprove any link between thiomersal and autism. However, they conclude that a causal connection between thiomersal and autism is "biologically plausible".
- 2002 - The USA Centers for Disease Control (CDC) and the USA Food and Drug Administration (FDA) state that: although thiomersal was to be discontinued in some paediatric vaccines, they would not be recalling any unused stocks, as there is no proof that low doses of thiomersal is dangerous, and that the change was purely cautionary.
- 2004 - The Institute of Medicine, based on new information from epidemiological studies undertaken since its 2001 report, rejects the hypothetical causative link between thiomersal and autism.
- 2004 - A small case-control study found no difference in the hair and blood mercury levels in children with ASD compared to normal children. However, in 2007 significant statistical errors were identified in this study, and were acknowledged by one of the study's authors. The p-value for mercury blood levels was corrected from .15 to .056, which is almost low enough to reach the (somewhat-arbitrary) level of .05 commonly used to report statistically significant results.
- 2005 - Robert F. Kennedy, Jr. authored an article in the June, 2005 Rolling Stone, alleging connections between thimerosal in vaccines and autism.
- 2006 - In the latest review by the WHO committee, the conclusion previously reached was reaffirmed that there is no evidence of toxicity in infants, children or adults exposed to thiomersal in vaccines.
- 2007 - In February, the U.S. National Institute of Mental Health (NIMH) halted an experiment that gave the chelating agent DMSA to children with autism whose blood had detectable but nontoxic mercury or lead. The experiment, by Susan Swedo, head of autism research at NIMH, had begun in September 2006 but was halted after a 2007 report showed that chelating agents could cause cognitive problems in rats; Swedo decided that NIMH's limited resources were better focused on a different experiment involving minocycline in children with regressive autism. Critics said the chelation experiment posed a risk to children for what is sure to be no medical gain for them; proponents said the therapy is in broad use and the experiment would provide scientific evidence about any benefits or dangers.
- 2007 - Theresa and Michael Cedillo, the parents of 12-year-old Michelle Cedillo asked a federal court, the so-called "vaccine court", Monday June 11, to find that their child's autism was caused by common childhood vaccines.
- 2007 - Mike Enzi, the ranking member on the United States Senate Committee on Health, Education, Labor, and Pensions, issued a report assessing allegations about thimerosal and autism. The report substantiated allegations that there were shortcomings in the Institute of Medicine's conflict screening procedures, that thimerosal is used in third-world childhood vaccines, and that late-1990s EPA mercury guidelines were inappropriate for vaccines and caused many individuals to conclude that ethyl mercury can be linked to autism. Several other allegations were not substantiated.
- 2008 - A study found that autism rates for children in California increased each quarter from January 1995 through March 2007, despite the removal of all but trace amounts of thiomersal from childhood vaccines since the 1999 national recommendation. The study analyzed data from the California Department of Developmental Services database, which had been systematically used by proponents of the thimerosal hypothesis to argue that the rising number of children accessing these services was linked to increased use of thimerosal in vaccines.
- 2008 - A study that examined the ethylmercury from thiomersal in vaccines found that the half-life of blood mercury after vaccination averages 3.7 days for newborns and infants, much shorter than the 44 days for methylmercury. The shorter half-life suggests that thiomersal in vaccines is not as risky as was feared, and that a new risk assessment is needed.
- 2009 - A study of two kinds of pertussis vaccines given to Italian children in the 1990s, with differing amounts of thiomersal, performed a large number of statistical comparisons of standardized neuropsychological tests ten years after immunization, and found a few small associations between thiomersal exposure and neuropsychological development, which might be attributable to chance.
References[edit | edit source]
- Burton D (2003). Mercury in medicine report. Congressional Record 149: E1011–30.
- Offit PA (2007). Thimerosal and vaccines—a cautionary tale. N Engl J Med 357 (13): 1278–9.
- Doja A, Roberts W (2006). Immunizations and autism: a review of the literature. Can J Neurol Sci 33 (4): 341–6.
- Thimerosal in vaccines. Center for Biologics Evaluation and Research, U.S. Food and Drug Administration. URL accessed on 2007-10-01.
- Baker JP (2008). Mercury, vaccines, and autism: one controversy, three histories. Am J Public Health 98 (2): 244–53.
- Thimerosal in vaccines: frequently asked questions (FAQs). Center for Biologics Evaluation and Research, U.S. Food and Drug Administration. URL accessed on 2008-07-22.
- Autism cases in vaccine court:
- Sugarman SD (2007). Cases in vaccine court—legal battles over vaccines and autism. N Engl J Med 357 (13): 1275–7.
- U.S. Court of Federal Claims. Vaccine Program/Office of Special Masters Omnibus Autism Proceeding. URL accessed on 2007-11-24.
- World Health Organization. Thiomersal and vaccines: questions and answers. URL accessed on 2007-07-22.
- Centers for Disease Control (2007-01-08). Mercury and Vaccines (Thimerosal). URL accessed on 2007-07-22.
- Nelson KB, Bauman ML (March 2003). Thimerosal and autism?. Pediatrics 111 (3): 674–9.
- Thompson WW, Price C, Goodson B et al. (2007). Early thimerosal exposure and neuropsychological outcomes at 7 to 10 years. N Engl J Med 357 (13): 1281–92.
- Heron J, Golding J, ALSPAC Study Team (2004). Thimerosal exposure in infants and developmental disorders: a prospective cohort study in the United kingdom does not support a causal association. Pediatrics 114 (3): 577–83.
- Madsen KM, Lauritsen MB, Pedersen CB et al. (2004). Thimerosal and the occurrence of autism: negative ecological evidence from Danish population-based data. Pediatrics 112 (3): 604–6.
- Hviid A, Stellfeld M, Wohlfahrt J, Melbye M (2003). Association between thimerosal-containing vaccine and autism. JAMA 290 (13): 1763–6.
- Andrews N, Miller E, Grant A, Stowe J, Osborne V, Taylor B (2004). Thimerosal exposure in infants and developmental disorders: a retrospective cohort study in the United kingdom does not support a causal association. Pediatrics 114 (3): 584–91.
- Fombonne E, Zakarian R, Bennett A, Meng L, McLean-Heywood D (2006). Pervasive developmental disorders in Montreal, Quebec, Canada: prevalence and links with immunizations. Pediatrics 118 (1): e139–50.
- Schechter R, Grether JK (2008). Continuing increases in autism reported to California's developmental services system: mercury in retrograde. Arch Gen Psychiatry 65 (1): 19–24.
- Stehr-Green P, Tull P, Stellfeld M, Mortenson PB, Simpson D (2003). Autism and thimerosal-containing vaccines: lack of consistent evidence for an association. Am J Prev Med 25 (2): 101–6.
- American Academy of Pediatrics (1999-09-01). Joint Statement of the American Academy of Pediatrics and the US Public Health Service (USPHS). URL accessed on 2007-07-22.
- Ball LK, Ball R, Pratt RD (2001). An assessment of thimerosal use in childhood vaccines. Pediatrics 107 (5): 1147–54.
- Immunization Safety Review Committee, Board on Health Promotion and Disease Prevention, Institute of Medicine (2001). Immunization Safety Review: Thimerosal-Containing Vaccines and Neurodevelopmental Disorders, Washington, DC: National Academy Press.
- DeStefano F (2007). Vaccines and autism: evidence does not support a causal association. Clin Pharmacol Ther 82 (6): 756–9.
- Burbacher TM, Shen DD, Liberato N, Grant KS, Cernichiari E, Clarkson T (2005). Comparison of blood and brain mercury levels in infant monkeys exposed to methylmercury or vaccines containing thimerosal. Environ Health Perspect 113 (8): 1015–21.
- In vitro tests:
- James SJ, Slikker W III, Melnyk S, New E, Pogribna M, Jernigan S (2005). Thimerosal neurotoxicity is associated with glutathione depletion: protection with glutathione precursors. Neurotoxicology 26 (1): 1–8.
- Baskin DS, Ngo H, Didenko VV (2003). Thimerosal induces DNA breaks, caspase-3 activation, membrane damage, and cell death in cultured human neurons and fibroblasts. Toxicol Sci 74 (2): 361–8.
- Ueha-Ishibashi T, Oyama Y, Nakao H et al. (2004). Effect of thimerosal, a preservative in vaccines, on intracellular Ca2+ concentration of rat cerebellar neurons. Toxicology 195 (1): 77–84.
- Hornig M, Chian D, Lipkin WI (2004). Neurotoxic effects of postnatal thimerosal are mouse strain dependent. Mol Psychiatry 9 (9): 833–45.
- Berman RF, Pessah IN, Mouton PR, Mav D, Harry J (2008). Low level neonatal thimerosal exposure: further evaluation of altered neurotoxic potential in SJL mice. Toxicol Sci 101 (2): 294–309.
- Branch DR (2008). Gender-selective toxicity of thimerosal. Exp Toxicol Pathol.
- includeonly>Olmsted D. "The age of autism: the last word", UPI, 2007-07-18. Retrieved on 2007-07-23.
- Szpir M (2006). Tracing the origins of autism: a spectrum of new studies. Environ Health Perspect 114 (7): A412–8.
- Geier studies:
- Geier DA, Geier MR (2006). A meta-analysis epidemiological assessment of neurodevelopmental disorders following vaccines administered from 1994 through 2000 in the United States. Neuro Endocrinol Lett 27 (4): 401–13.
- Geier DA, Geier MR (2006). An assessment of downward trends in neurodevelopmental disorders in the United States following removal of Thimerosal from childhood vaccines. Med Sci Monit 12 (6): CR231–9.
- Geier DA, Geier MR (2006). An evaluation of the effects of thimerosal on neurodevelopmental disorders reported following DTP and Hib vaccines in comparison to DTPH vaccine in the United States. J Toxicol Environ Health A 69 (15): 1481–95.
- Geier DA, Geier MR (2006). Early downward trends in neurodevelopmental disorders following removal of thimerosal-containing vaccines. J Am Phys Surg 11 (1): 8–13.
- Geier DA, Geier MR (2007). A prospective study of mercury toxicity biomarkers in autistic spectrum disorders. J Toxicol Environ Health A 70 (20): 1723–30.
- Young HA, Geier DA, Geier MR (2008). Thimerosal exposure in infants and neurodevelopmental disorders: an assessment of computerized medical records in the Vaccine Safety Datalink. J Neurol Sci 271 (1–2): 110–8.
- Parker SK, Schwartz B, Todd J, Pickering LK (2004). Thimerosal-containing vaccines and autistic spectrum disorder: a critical review of published original data. Pediatrics 114 (3): 793–804. Erratum (2005) Pediatrics 115 (1), 200. DOI:10.1542/peds.2004-2402 . PMID 15630018.
- Rutter M (2005). Incidence of autism spectrum disorders: changes over time and their meaning. Acta Paediatr 94 (1): 2–15.
- Mutter J, Naumann J, Schneider R, Walach H, Haley B (2005). Mercury and autism: accelerating evidence?. Neuro Endocrinol Lett 26 (5): 439–46.
- Institute for Vaccine Safety (2007-07-12). Thimerosal Content in Some US Licensed Vaccines. URL accessed on 2007-07-23.
- Food and Drug Administration (2004-09-09). Mercury in Plasma-Derived Products. URL accessed on 2007-07-23.
- Immunization Safety Review Committee, Board on Health Promotion and Disease Prevention, Institute of Medicine (2004). Immunization Safety Review: Vaccines and Autism, Washington, DC: The National Academies Press.
- Verstraeten T, Davis RL, DeStefano F et al. (2003). Safety of thimerosal-containing vaccines: a two-phased study of computerized health maintenance organization databases. Pediatrics 112 (5): 1039–48.
- includeonly>Allen A. "Thiomersal on trial: the theory that vaccines cause autism goes to court", Slate, 2007-05-28. Retrieved on 2008-01-30.
- American Medical Association (2004-05-18). AMA Welcomes New IOM Report Rejecting Link Between Vaccines and Autism. URL accessed on 2007-07-23.
- American Academy of Pediatrics (2004-05-18). What Parents Should Know About Thimerosal. URL accessed on 2007-07-23.
- Kurt TL (2006). ACMT position statement: the Iom report on thimerosal and autism. J Med Toxicol 2 (4): 170–1.
- Infectious Diseases and Immunization Committee, Canadian Paediatric Society (2007). Autistic spectrum disorder: No causal relationship with vaccines. Paediatr Child Health 12 (5): 393–5. Also published (2007) in Can J Infect Dis Med Microbiol 18 (3): 177–9. PMID 18923720.
- National Advisory Committee on Immunization (2007). Thimerosal: updated statement. An Advisory Committee Statement. Can Commun Dis Rep 33 (ACS-6): 1–13.
- European Medicines Agency (2004-03-24). EMEA Public Statement on Thiomersal in Vaccines for Human Use. URL accessed on 2007-07-22.
- includeonly>Luscombe R. "Charity chief quits over autism row", Observer, 2009-01-25. Retrieved on 2009-02-01.
- National Vaccine Injury Compensation Program statistics reports. Health Resources and Services Administration. URL accessed on 2008-01-22.
- includeonly>Stobbe M, Marchione M. "Analysis: vaccine-autism link unproven", Associated Press, 2008-03-07. Retrieved on 2008-06-06.
- Honey K (2008). Attention focuses on autism. J Clin Invest 118 (5): 1586–7.
- Mercury and vaccines (thimerosal). Centers for Disease Control and Prevention. URL accessed on 2007-10-01.
- Ip P, Wong V, Ho M, Lee J, Wong W (2004). Mercury exposure in children with autistic spectrum disorder: case-control study. J Child Neurol 19 (6): 431–4.
- DeSoto MC, Hitlan RT (2007). Blood levels of mercury are related to diagnosis of autism: a reanalysis of an important data set. J Child Neurol 22 (11): 1308–11.
- Acknowledgement by Wong:
- Brumback RA (2004). Note from editor-in-chief about erratum for Ip et al article. J Child Neurol 22 (11): 1321–3.
- Wong V (2004). Erratum. J Child Neurol 22 (11): 1324.
- Brumback RA (2008). A never ending saga: the mercury and autism articles by Ip et al. J Child Neurol 23 (7): 725.
- Deadly Immunity : Rolling Stone
- Statement on thiomersal (World Health Organization, July 2006)
- Stokstad E (2008). Stalled trial for autism highlights dilemma of alternative treatments. Science 321 (5887): 326.
- Enzi MB (2007). Thimerosal and autism spectrum disorders: alleged misconduct by government agencies and private entities. (PDF) URL accessed on 2007-10-04.
- Fombonne E (2008). Thimerosal disappears but autism remains. Arch Gen Psychiatry 65 (1): 15–6.
- Pichichero ME, Gentile A, Giglio N et al. (2008). Mercury levels in newborns and infants after receipt of thimerosal-containing vaccines. Pediatrics 121 (2): e208–14.
- Tozzi AE, Bisiacchi P, Tarantino V et al. (2009). Neuropsychological performance 10 years after immunization in infancy with thimerosal-containing vaccines. Pediatrics 132 (2): 475–82.
Vaccination/Vaccine (and Immunization, Inoculation. See also List of vaccine topics and Epidemiology)
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