Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)

This article needs rewriting to enhance its relevance to psychologists..
Please help to improve this page yourself if you can..

Tandem repeats are a type of repetitive DNA and occur in DNA when a pattern of two or more nucleotides is repeated and the repetitions are directly adjacent to each other. [1]

Example[edit | edit source]

An example would be:


in which the sequence A-T-T-C-G is repeated three times.

Terminology[edit | edit source]

When between 10 and 60 nucleotides are repeated, it is called a minisatellite. Those with fewer are known as microsatellites or short tandem repeats.

When exactly two nucleotides are repeated, it is called a "dinucleotide repeat" (for example: ACACACAC...). The microsatellite instability in hereditary nonpolyposis colon cancer most commonly affects such regions.[2]

When three nucleotides are repeated, it is called a "trinucleotide repeat" (for example: CAGCAGCAGCAG...), and abnormalities in such regions can give rise to trinucleotide repeat disorders.

When the number is not known, variable, or irrelevant, it is sometimes called a variable number tandem repeat (VNTR). MeSH classifies variable number tandem repeats under minisatellites.[3]

Uses[edit | edit source]

Tandem repeat describes a pattern that helps determine an individual's inherited traits.

Tandem repeats can be very useful in determining parentage. Short tandem repeats are used for certain genealogical DNA tests.

DNA is examined from microsatellites within the chromosomal DNA. Minisatellite is another way of saying special regions of the loci. Polymerase chain reaction (or PCR) is performed on the minisatellite areas. The PCR must be performed on each organism being tested. The amplified material is then run through electrophoresis. By checking the percentage of bands that match, parentage is determined.

In the field of Computer Science, tandem repeats in strings (e.g. DNA sequences) can be efficiently detected using suffix trees or suffix arrays.

Studies in 2004 linked the unusual genetic plasticity of dogs to mutations in tandem repeats.[4]

See also[edit | edit source]

References[edit | edit source]

  1. MeSH Tandem+Repeat
  2. PMID 10321739 (PMID 10321739)
    Citation will be completed automatically in a few minutes. Jump the queue or expand by hand
  3. MeSH Variable+Number+of+Tandem+Repeats
  4. DOI:10.1126/science.306.5705.2172
    This citation will be automatically completed in the next few minutes. You can jump the queue or expand by hand

External links[edit | edit source]

Template:Repeated sequence

This page uses Creative Commons Licensed content from Wikipedia (view authors).
Community content is available under CC-BY-SA unless otherwise noted.