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- This article is about the self administration of drugs in humans. For the operant study of self reward in animals see: Self-administration.
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The psychology of such behavior within the specific context of using recreational drugs, psychoactive drugs, alcohol, and other self-soothing forms of behavior to alleviate symptoms of mental distress, stress and anxiety, including mental illnesses and/or psychological trauma, is particularly unique and can serve as a serious detriment to physical and mental health if motivated by addictive mechanisms.
Self-medication is often seen as gaining personal independence from established medicine, and it can be seen as a human right, implicit in, or closely related to the right to refuse professional medical treatment
- 1 Definition
- 2 Psychology and psychiatry
- 3 Infectious disease
- 4 Physicians and medical students
- 5 Children
- 6 Regulation
- 7 Self medication with alcohol
- 8 Self medication and drugs of addiction
- 9 See also
- 10 References & Bibliography
- 11 Key texts
- 12 Additional material
- 13 =Dissertations
Definition[edit | edit source]
Generally speaking, self-medication is defined as "the use of drugs to treat self-diagnosed disorders or symptoms, or the intermittent or continued use of a prescribed drug for chronic or recurrent disease or symptoms"
Psychology and psychiatry[edit | edit source]
Self-medication hypothesis[edit | edit source]
As different drugs have different effects, they may be used for different reasons. According to the self-medication hypothesis (SMH), the individuals' choice of a particular drug is not accidental or coincidental, but instead, a result of the individuals' psychological condition, as the drug of choice provides relief to the user specific to his or her condition. Specifically, addiction is hypothesized to function as a compensatory means to modulate effects and treat distressful psychological states, whereby individuals choose the drug that will most appropriately manage their specific type of psychiatric distress and help them achieve emotional stability.
The self-medication hypothesis (SMH) originated in papers by Edward Khantzian, Mack and Schatzberg, David F. Duncan, and a response to Khantzian by Duncan. The SMH initially focused on heroin use, but a follow-up paper added cocaine. The SMH was later expanded to include alcohol, and finally all drugs of addiction.
According to Khantzian's view of addiction, drug users compensate for deficient ego function by using a drug as an "ego solvent", which acts on parts of the self that are cut off from consciousness by defense mechanisms. According to Khantzian, drug dependent individuals generally experience more psychiatric distress than non-drug dependent individuals, and the development of drug dependence involves the gradual incorporation of the drug effects and the need to sustain these effects into the defensive structure-building activity of the ego itself. The addict's choice of drug is a result of the interaction between the psychopharmacologic properties of the drug and the affective states from which the addict was seeking relief. The drug's effects substitute for defective or non-existent ego mechanisms of defense. The addict's drug of choice, therefore, is not random.
While Khantzian takes a psychodynamic approach to self-medication, Duncan's model focuses on behavioral factors. Duncan described the nature of positive reinforcement (e.g., the "high feeling", approval from peers), negative reinforcement (e.g. reduction of negative affect) and avoidance of withdrawal symptoms, all of which are seen in those who develop problematic drug use, but are not all found in all recreational drug users. While earlier behavioral formulations of drug dependence using operant conditioning maintained that positive and negative reinforcement were necessary for drug dependence, Duncan maintained that drug dependence was not maintained by positive reinforcement, but rather by negative reinforcement. Duncan applied a public health model to drug dependence, where the agent (the drug of choice) infects the host (the drug user) through a vector (e.g., peers), while the environment supports the disease process, through stressors and lack of support.
Khantzian revisited the SMH, suggesting there is more evidence that psychiatric symptoms, rather than personality styles, lie at the heart of drug use disorders. Khantzian specified that the two crucial aspects of the SMH were that (1) drugs of abuse produce a relief from psychological suffering and (2) the individual's preference for a particular drug is based on its psychopharmacological properties. The individual's drug of choice is determined through experimentation, whereby the interaction of the main effects of the drug, the individual's inner psychological turmoil, and underlying personality traits identify the drug that produces the desired effects.
Meanwhile, Duncan's work focuses on the difference between recreational and problematic drug use. Data obtained in the Epidemiologic Catchment Area Study demonstrated that only 20% of drug users ever experience an episode of drug abuse (Anthony & Helzer, 1991), while data obtained from the National Comorbidity Study demonstrated that only 15% of alcohol users and 15% of illicit drug users ever become dependent. A crucial determinant of whether a drug user develops drug abuse is the presence or absence of negative reinforcement, which is experienced by problematic users, but not by recreational users. According to Duncan, drug dependence is an avoidance behavior, where an individual finds a drug that produces a temporary escape from a problem, and taking the drug is reinforced as an operant behavior.
Specific mechanisms[edit | edit source]
Some mental illness sufferers attempt to correct their illnesses by use of certain drugs. Depression is often self-medicated with alcohol, tobacco, cannabis, or other mind-altering drug use. While this may provide immediate relief of some symptoms such as anxiety, it may evoke and/or exacerbate some symptoms of several kinds of mental illnesses that are already latently present, and may lead to addiction/dependence, among other side effects of long-term use of the drug.
Due to the different effects of the different classes of drugs, the SMH postulates that the appeal of a specific class of drugs differs from person to person. In fact, some drugs may be aversive for individuals for whom the effects could worsen affective deficits.
CNS depressants[edit | edit source]
Alcohol and sedative/hypnotic drugs, such as barbiturates and benzodiazepines, are central nervous system (CNS) depressants that lower inhibitions via anxiolysis. Depressants produce feelings of relaxation and sedation, while relieving feelings of depression and anxiety. Though they are generally ineffective antidepressants, as most are short-acting, the rapid onset of alcohol and sedative/hypnotics softens rigid defenses and, in low to moderate doses, provides relief from depressive affect and anxiety. As alcohol also lowers inhibitions, alcohol is also hypothesized to be used by those who normally constrain emotions by attenuating intense emotions in high or obliterating doses, which allows them to express feelings of affection, aggression and closeness. People with social anxiety disorder commonly use these drugs to overcome their highly set inhibitions.
Psychostimulants[edit | edit source]
Psychostimulants, such as cocaine, amphetamines, methylphenidate, caffeine, and nicotine, produce improvements in physical and mental functioning, including increased energy and feelings of euphoria. Stimulants tend to be used by individuals who experience depression, to reduce anhedonia and increase self-esteem. The SMH also hypothesizes that hyperactive and hypomanic individuals use stimulants to maintain their restlessness and heighten euphoria. Additionally, stimulants are useful to individuals with social anxiety by helping individuals break through their inhibitions.
Opiates[edit | edit source]
Opiates, such as heroin and morphine, function as an analgesic by binding to opioid receptors in the brain and gastrointestinal tract. This binding reduces the perception of and reaction to pain, while also increasing pain tolerance. Opiates are hypothesized to be used as self-medication for aggression and rage. Opiates are effective anxiolytics, mood-stabilizers, and anti-depressants, however, people tend to self-medicate anxiety and depression with depressants and stimulants respectively, though this is by no means an absolute analysis.
Cannabis[edit | edit source]
Cannabis is paradoxical in that it simultaneously produces stimulating, sedating and mildly psychedelic properties and both anxiolytic or anxiogenic properties, depending on the individual and circumstances of use. Depressant properties are more obvious in occasional users, and stimulating properties are more common in chronic users. Khantzian noted that research had not sufficiently addressed a theoretical mechanism for cannabis, and therefore did not include it in the SMH. Cannabis is commonly used to self-medicate individuals with attention deficit hyperactivity disorder, which has shown to improve symptoms for individuals with ADHD in studies.
Effectiveness[edit | edit source]
Self medicating excessively for prolonged periods of time with benzodiazepines or alcohol often makes the symptoms of anxiety or depression worse. This is believed to occur as a result of the changes in brain chemistry from long-term use. Of those who seek help from mental health services for conditions including anxiety disorders such as panic disorder or social phobia, approximately half have alcohol or benzodiazepine dependence issues.
Sometimes anxiety precedes alcohol or benzodiazepine dependence but the alcohol or benzodiazepine dependence acts to keep the anxiety disorders going, often progressively making them worse. However, some people addicted to alcohol or benzodiazepines, when it is explained to them that they have a choice between ongoing poor mental health or quitting and recovering from their symptoms, decide on quitting alcohol or benzodiazepines or both. It has been noted that every individual has an individual sensitivity level to alcohol or sedative hypnotic drugs, and what one person can tolerate without ill health, may cause another to suffer very ill health, and even moderate drinking can cause rebound anxiety syndrome and sleep disorders. A person suffering the toxic effects of alcohol will not benefit from other therapies or medications, as these do not address the root cause of the symptoms.
Infectious disease[edit | edit source]
Self-medication with antibiotics is commonplace in some countries, such as Greece. Such use is cited as a potential factor in the incidence of certain antibiotic resistant bacterial infections in places like Nigeria.
In a questionnaire designed to evaluate self-medication rates amongst the population of Khartoum, Sudan, 48.1% of respondents reported self-medicating with antibiotics within the past 30 days, 43.4% reported self-medicating with antimalarials, and 17.5% reported self-medicating with both. Overall, the total prevalence of reported self-medication with one or both classes of anti-infective agents within the past month was 73.9%. Furthermore, according to the associated study, data indicated that self-medication "varies significantly with a number of socio-economic characteristics" and the "main reason that was indicated for the self-medication was financial constraints".
Physicians and medical students[edit | edit source]
In a survey of West Bengal, India undergraduate medical school students, 57% reported self-medicating. The type of drugs most frequently used for self-medication were antibiotics (31%), analgesics (23%), antipyretics (18%), antiulcerics (9%), cough suppressants (8%), multivitamins (6%), and anthelmintics (4%).
Children[edit | edit source]
A study of Luo children in western Kenya found that 19% reported engaging in self-treatment with either herbal or pharmaceutical medicine. Proportionally, boys were much more likely to self-medicate using conventional medicine than herbal medicine as compared with girls, a phenomenon which was theorized to be influenced by their relative earning potential.
Regulation[edit | edit source]
- Main article: Regulation of therapeutic goods
Self-medication is highly regulated in much of the world and many classes of drugs are available for administration only upon prescription by licensed medical personnel. Safety, social order, commercialization, and religion have historically been among the prevailing factors that lead to such prohibition.
Self medication with alcohol[edit | edit source]
Self medication and drugs of addiction[edit | edit source]
See also[edit | edit source]
- Biodiversity and drugs
- Comfort food
- Drug self administration
- Drug therapy
- Dual diagnosis
- Placebo effect
- Psychological trauma
References & Bibliography[edit | edit source]
- Kirstin Murray. Distressed doctors pushed to the limit. Australian Broadcasting Corporation. URL accessed on 27 March 2011.
- Dr Vivek Benegal. Addicted to alcohol? Here's why. India Today. URL accessed on 27 March 2011.
- Howard Altman. Military suicide rates surge. Tampa Bay Online. URL accessed on 27 March 2011.
- Benefits and risks of self medication
- Three arguments against prescription requirements, Jessica Flanigan, BMJ Group Journal of Medical Ethics 26 July 2012, accessed 20 August 2013
- "Guidelines for the Regulatory Assessment of Medicinal Products for use in Self-Medication" (PDF), WHO/EDM/QSM/00.1, Geneva: World Health Organization, 2000
- Awad, Abdelmoneim, Idris Eltayeb, Lloyd Matowe, Lukman Thalib (2005-08-12). Self-medication with antibiotics and antimalarials in the community of Khartoum State, Sudan.. Journal of Pharmacy & Pharmaceutical Sciences 8 (2): 326–331.
- Khantzian, E.J. (1997). The self-medication hypothesis of drug use disorders: A reconsideration and recent applications. Harvard Review of Psychiatry, 4, 231-244.
- Khantzian, E.J. (2003). The self-medication hypothesis revisited: The dually diagnosed patient. Primary Psychiatry, 10, 47-48, 53-54.
- Khantzian, E.J., Mack, J.F., & Schatzberg, A.F. (1974). Heroin use as an attempt to cope: Clinical observations. American Journal of Psychiatry, 131, 160-164.
- Duncan, D.F. (1974a). Reinforcement of drug abuse: Implications for prevention. Clinical Toxicology Bulletin, 4, 69-75.
- Duncan, D.F. (1974b). Letter: Drug abuse as a coping mechanism. American Journal of Psychiatry, 131, 174.
- Khantzian, E.J. (1985). The self-medication hypothesis of addictive disorders: Focus on heroin and cocaine dependence. American Journal of Psychiatry, 142, 1259-1264.
- Khantzian, E.J., Halliday, K.S., & McAuliffe, W.E. (1990). Addiction and the vulnerable self: Modified dynamic group therapy for drug abusers. New York: Guilford Press.
- Khantzian, E.J. (1999). Treating addiction as a human process. Northvale, NJ: Jason Aronson.
- Duncan, D.F. (1975). The acquisition, maintenance and treatment of polydrug dependence: A public health model. Journal of Psychedelic Drugs, 7, 209-213. http://www.duncan-associates.com/PUBLICHEALTHMODEL.htm
- Duncan, D.F., & Gold, R.S. (1983). Cultivating drug use: A strategy for the 80s. Bulletin of the Society of Psychologists in Addictive Behaviors, 2, 143-147. http://www.addictioninfo.org/articles/263/1/Cultivating-Drug-Use/Page1.html
- Anthony, J., Warner, L., & Kessler, R. (1994). Comparative epidemiology of dependence on tobacco, alcohol, controlled substances and inhalants: Basic findings from the National Comorbidity Study. Experimental and Clinical Psychopharmacology, 2, 244-268.
- Nicholson, T., Duncan, D.F., & White, J.B. (2002). Is recreational drug use normal? Journal of Drug Use, 7, 116-123. http://www.duncan-associates.com/Is-Recreational-Drug-Use-Normal.pdf
- Self-Medication With Alcohol and Drugs by Persons With Severe Mental Illness
- Mental Illness: The Challenge Of Dual Diagnosis
- Post Traumatic Stress Disorder
- Sarah W. Book, M.D., and Carrie L. Randall, Ph.D. Social anxiety disorder and alcohol use. Alcohol Research and Health, 2002.
- Diagnosis and Treatment of Attention Deficit Hyperactivity Disorder. NIH Consensus Statement Online 1998 Nov 16-18; 16(2): 1-37. Accessed October 2011.
- Professor C Heather Ashton (1987). Benzodiazepine Withdrawal: Outcome in 50 Patients. British Journal of Addiction 82: 655–671.
- Michelini S, Cassano GB, Frare F, Perugi G (July 1996). Long-term use of benzodiazepines: tolerance, dependence and clinical problems in anxiety and mood disorders. Pharmacopsychiatry 29 (4): 127–34.
- Wetterling T, Junghanns K (Dec 2000). Psychopathology of alcoholics during withdrawal and early abstinence. Eur Psychiatry 15 (8): 483–8.
- Cowley DS (Jan 1, 1992). Alcohol abuse, substance abuse, and panic disorder. Am J Med 92 (1A): 41S–8S.
- Cosci F, Schruers KR, Abrams K, Griez EJ (Jun 2007). Alcohol use disorders and panic disorder: a review of the evidence of a direct relationship. J Clin Psychiatry 68 (6): 874–80.
- Cohen SI (February 1995). Alcohol and benzodiazepines generate anxiety, panic and phobias. J R Soc Med 88 (2): 73–7.
- Skliros, Eystathios, Panagiotis Merkouris, Athanasia Papazafiropoulou, Aristofanis Gikas, George Matzouranis, Christos Papafragos, Ioannis Tsakanikas, Irene Zarbala, Alexios Vasibosis, Petroula Stamataki, Alexios Sotiropoulos (2010-08-08). Self-medication with antibiotics in rural population in Greece: a cross-sectional multicenter study. BMC Family Practice 11 (58).
- Sapkota, Amy R., Morenike E. Coker, Rachel E. Rosenberg Goldstein, Nancy L. Atkinson, Shauna J. Sweet, Priscilla O. Sopeju, Modupe T. Ojo, Elizabeth Otivhia, Olayemi O. Ayepola, Olufunmiso O. Olajuyigbe, Laura Shireman, Paul S. Pottinger, Kayode K. Ojo (2010-10-15). Self-medication with antibiotics for the treatment of menstrual symptoms in southwest Nigeria: a cross-sectional study. BMC Public Health 10 (610).
- Pan, Hui, Binglin Cui, Dangui Zhang, Jeremy Farrar, Frieda Law, William Ba-Thein (2012-07-20). Prior Knowledge, Older Age, and Higher Allowance Are Risk Factors for Self-Medication with Antibiotics among University Students in Southern China. PLoS ONE 7 (7).
- Banerjee, I., T. Bhadury (2012 April–June). Self-medication practice among undergraduate medical students in a tertiary care medical college, West Bengal. Journal of Postgraduate Medicine 58 (2): 127–131.
- Nalini, G. K. (2010). Self-Medication among Allopathic medical Doctors in Karnataka, India. British Journal of Medical Practitioners 3 (2).
- Geissler, P.W ., K. Nokes, R. J. Prince, R. Achieng Odhiambo, J. Aagaard-Hansen, J. H. Ouma (June 2000). Children and medicines: self-treatment of common illnesses among Luo school children in western Kenya. Social Science & Medicine 50 (12): 1771–1783.
Key texts[edit | edit source]
Books[edit | edit source]
- Albanese, M. J., & Khantzian, E. J. (2002). Self-medication theory and modified dynamic group therapy. New York, NY: Haworth Press.
- Crawley, B. (1993). Self-medication and the elderly. Thousand Oaks, CA: Sage Publications, Inc.
- Harchik, A. E. (1994). Self-medication skills. Baltimore, MD: Paul H Brookes Publishing.
- Weiss, R. D., & Mirin, S. M. (1997). Substance abuse as an attempt at self-medication. New York, NY: New York University Press.
Papers[edit | edit source]
- Achalu, ED (2002).The self-medication hypothesis: a review of the two major theories and the research evidence. SMH: Recent Developments on the Self-Medication Hypothesis, 1(10), id1. 
- Blenkinsopp A, Bradley C (1996). Over the counter drugs: the future for self medication. British Medical Journal, 312, 835.
- Duncan DF (1974a). Reinforcement of drug abuse: Implications for prevention. Clinical Toxicology Bulletin, 4(2), 69.
- Duncan DF (1974b). Drug abuse as a coping mechanism. American Journal of Psychiatry, 131(6), 724.
- Duncan DF (1975).The acquisition, maintenance and treatment of polydrug dependence: A public health model. Journal of Psychedelic Drugs, 7(2), 201.
- Hughes CM, McElnay JC, Fleming GF (2001). Benefits and risks of self medication. Drug Safety, 24, 1027
- Khantzian, EJ, Mack JE, Schatzberg AF (1974). Heroin use as an attempt to cope: clinical observations. American Journal of Psychiatry, 131(2), 160.
- Khantzian EJ (1985). The self-medication hypothesis of addictive disorders: focus on heroin and cocaine dependence. American Journal of Psychiatry, 142(11), 1259.
- Khantzian EJ (1990) Self-regulation and self-medication factors in alcoholism and the addictions. similarities and differences. Recent Developments in Alcoholism, 8, 255.
- Khantzian, E. J. (1997). The self-medication hypothesis of substance use disorders: A reconsideration and recent applications: Harvard Review of Psychiatry Vol 4(5) Jan-Feb 1997, 231-244.
- Khantzian, E. J. (2003). The Self-Medication Hypothesis Revisited: The Dually Diagnosed Patient: Primary Psychiatry Vol 10(9) Sep 2003, 47-48, 53-54.
- Khantzian, E. J. (2003). Understanding Addictive Vulnerability: An Evolving Psychodynamic Perspective: Neuro-Psychoanalysis Vol 5(1) 2003, 5-21.
- Khantzian, E. J. (2003). "Understanding Addictive Vulnerability: An Evolving Psychodynamic Perspective": Response to Commentaries: Neuro-Psychoanalysis Vol 5(1) 2003, 53-56.
- Wazaify M, Shields E, Hughes CM, McElnay JC (2005). Societal perspectives on over-the-counter (OTC) medicines. Family Practice, 22: 170-176.
Additional material[edit | edit source]
Books[edit | edit source]
- Blazer, D. G. (2004). Alcohol and Drug Problems. Arlington, VA: American Psychiatric Publishing, Inc.
- Cheney, C. D. (1996). Medical nonadherence: A behavior analysis. New York, NY: Plenum Press.
- Huffman, M. A., & Wrangham, R. W. (1994). Diversity of medicinal plant use by chimpanzees in the wild. Cambridge, MA: Harvard University Press.
- Rand, C. S., & Weeks, K. (1998). Measuring adherence with medication regimens in clinical care and research. New York, NY: Springer Publishing Co.
Papers[edit | edit source]
- Adu-Sarkodie, Y. A. (1997). Antimicrobial self medication in patients attending a sexually transmitted diseases clinic: International Journal of STD & AIDS Vol 8(7) Jul 1997, 456-458.
- Aguilar, M. C., Gurpegui, M., Diaz, F. J., & De Leon, J. (2005). Nicotine dependence and symptoms in schizophrenia: Naturalistic study of complex interactions: British Journal of Psychiatry Vol 186(3) Mar 2005, 215-221.
- Aharonovich, E., Nguyen, H. T., & Nunes, E. V. (2001). Anger and depressive states among treatment-seeking drug abusers: Testing the psychopharmacological specificity hypothesis: The American Journal on Addictions Vol 10(4) Fal 2001, 327-334.
- Alao, A. O., Westmoreland, N., & Jindal, S. (2003). Drug addiction in sickle cell disease: Case report: International Journal of Psychiatry in Medicine Vol 33(1) 2003, 97-101.
- Ambrosio, E., Martin, S., Garcia-Lecumberri, C., & Crespo, J. A. (1999). The neurobiology of cannabinoid dependence: Sex differences and potential interactions between cannabinoid and opioid systems: Life Sciences Vol 65(6-7) Jul 1999, 687-694.
- Ankri, J., Beaufils, B., Ledisert, D., & Henrard, J. C. (1997). Behaviors toward medicine practiced at home by elderly people with chronic illnesses: Social Science & Medicine Vol 44(3) Feb 1997, 337-345.
- Arendt, M., Rosenberg, R., Fjordback, L., Brandholdt, J., Foldager, L., Sher, L., et al. (2007). Testing the self-medication hyppthesis of depression and aggression in cannabis-dependent subjects: Psychological Medicine Vol 37(7) Jul 2007, 935-945.
- Arikan, Z., Kuruoglu, A. C., & Aslan, S. (2002). Panic Disorder In Alcohol Dependency: A Retrospective Study: Bagimlik Dergisi Vol 3(1) Apr 2002, 9-14.
- Artz, M. B., Harnack, L. J., Duval, S. J., Armstrong, C., Arnett, D. K., & Luepker, R. V. (2006). Use of Nonprescription Medications for Perceived Cardiovascular Health: American Journal of Preventive Medicine Vol 30(1) Jan 2006, 78-81.
- Audrain, J., Lerman, C., Gomez-Caminero, A., Boyd, N. R., & Orleans, C. T. (1998). The role of trait anxiety in nicotine dependence: Journal of Applied Biobehavioral Research Vol 3(1) 1998, 29-42.
- Babalola, O. O., & Lamikanra, A. (2007). The response of students to malaria and malaria therapy in a university in southwest Nigeria: Research in Social & Administrative Pharmacy Vol 3(3) Sep 2007, 351-362.
- Bagshaw, R. J., Shaw, L. M., August, T., Young, M. L., & et al. (1993). Unregulated self-medication in an ambulatory surgery population: Aviation, Space, and Environmental Medicine Vol 64(4) Apr 1993, 324-326.
- Baillod, R. A. (1995). Home dialysis: Lessons in patient education: Patient Education and Counseling Vol 26(1-3) Sep 1995, 17-24.
- Balon, R. (2007). Psychiatrist attitudes toward self-treatment of their own depression: Psychotherapy and Psychosomatics Vol 76(5) Aug 2007, 306-310.
- Barrett, A. J. (2005). Rationalizing risk? The use of non-prescribed substances in severe and enduring mental illness: Journal of Substance Use Vol 10(6) Dec 2005, 341-346.
- Bartlome, J. A. (1992). Analysis of the factors influencing females' intention to self-medicate for vulvovaginal candidiasis: Dissertation Abstracts International.
- Bassols, A., Bosch, F., & Banos, J.-E. (2002). How does the general population treat their pain? A survey in Catalonia, Spain: Journal of Pain and Symptom Management Vol 23(4) Apr 2002, 318-328.
- Batel, P. (2000). Addiction and schizophrenia: European Psychiatry Vol 15(2) Mar 2000, 115-122.
- Berner, M. M., Kriston, L., Sitta, P., & Harter, M. (2008). Treatment of depressive symptoms and attitudes towards treatment options in a representative German general population sample: International Journal of Psychiatry in Clinical Practice Vol 12(1) Mar 2008, 5-10.
- Berzanskyte, A., Valinteliene, R., Haaijer-Ruskamp, F. M., Gurevicius, R., & Grigoryan, L. (2006). Self-medication with antibiotics in Lithuania: International Journal of Occupational Medicine & Environmental Health Vol 19(4) 2006, 246-253.
- Blume, A. W., Schmaling, K. B., & Marlatt, G. A. (2000). Revisiting the self-medication hypothesis from a behavioral perspective: Cognitive and Behavioral Practice Vol 7(4) Fal 2000, 379-384.
- Bolton, J., Cox, B., Clara, I., & Sareen, J. (2006). Use of Alcohol and Drugs to Self-Medicate Anxiety Disorders in a Nationally Representative Sample: Journal of Nervous and Mental Disease Vol 194(11) Nov 2006, 818-825.
- Boyer, E. W., Babu, K. M., Adkins, J. E., McCurdy, C. R., & Halpern, J. H. (2008). Self-treatment of opioid withdrawal using kratom (Mitragynia speciosa korth): Addiction Vol 103(6) Jun 2008, 1048-1050.
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=Dissertations[edit | edit source]
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- Miller, N. G. (1991). Decreasing medication abuse in psychiatric outpatients using special packaging: Dissertation Abstracts International.
- Miralles, M. A. (1993). Access to care and medication use among the ambulatory elderly in Rio de Janeiro, Brazil: Dissertation Abstracts International.
- Ostrowsky, M. K. (2007). Extending khantzian's self-medication hypothesis: An examination of low self-esteem, depression, alcohol use, marijuana use, and violent behavior. Dissertation Abstracts International Section A: Humanities and Social Sciences.
- Pabon, T. M. (2004). The self-medication theory of addictive disorders: Motivational aspects of drug addiction. Dissertation Abstracts International: Section B: The Sciences and Engineering.
- Rice, M. A. (1998). Concordant and discordant drug use in intimate relationships: A longitudinal study. Dissertation Abstracts International: Section B: The Sciences and Engineering.
- Robinson, R. J. (2008). Comorbidity of alcohol abuse and depression: Exploring the self-medication hypothesis. Dissertation Abstracts International: Section B: The Sciences and Engineering.
- Stawar, T. L. (1991). Perceptual learning style, modality-specific mnemonic elaboration strategies and achievement of severely psychiatrically disabled adults in self-medication management skills training: Dissertation Abstracts International.
- Stockwell, L. M. (1993). A qualitative exploration of medication-taking behaviors in the elderly: Dissertation Abstracts International.
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