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Poly drug use refers to the use two or more psychoactive drugs in combination to achieve a particular effect. In many cases, this makes the experience far more dangerous than taking the substances alone.

There are many popular drug combinations, including, but not limited to[1]:

While many recreational drug users use multiple drugs to increase intoxication for pleasurable effects, poly drug use can pertain to an increase in spiritual entheogenic properties, for example 2C-I and LSD or morning glory seeds and San Pedro cactus.

Poly drug use often carries with it more risk than use of a single drug, due to an increase in side effects, and unique pharmacological interactions.

The phenomenon is the subject of established academic literature (e.g., Scholey AB, Parrott AC, Buchanan T, Heffernan TM, Ling J, Rodgers J (2004). "Increased intensity of Ecstasy and polydrug use in the more experienced Ecstasy/MDMA users: a WWW study." Addictive Behaviors, 29, 743-752).

See alsoEdit

External linksEdit


  1. UMD Center for Substance Abuse Research. Ecstasy:CESAR.
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