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Picrotoxin chemical structure

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Chemical formula {{{chemical_formula}}}
Molecular weight 602.583 g/mol
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Picrotoxin, also known as cocculin, is a poisonous crystalline plant alkaloid, first isolated by Boullay in 1812.

Found primarily in Cocculus indicus and Anamirta cocculus, it has a strong physiological action. It acts as a non-competitive antagonist of GABA A receptors. As GABA itself is an inhibitory neurotransmitter, infusion of picrotoxin has a stimulative effect.

Chemical structure[edit | edit source]

Picrotoxin (C30H34O13) consists of two substances, picrotoxinin (C15H1606) and picrotin (C15H1807).

References[edit | edit source]

  • L. Dupont, O. Dideberg, J. Lamotte-Brasseur et L. Angenot (1976). Structure cristalline et moléculaire de la picrotoxine, C15H16O6.C15H18O7. Acta Cryst. B32: 2987–2993. (in French)

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