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Peptide YY3-36 (PYY) is a linear polypeptide consisting of 36 amino acids with structural homology to NPY and pancreatic polypeptide. PYY exerts its action through neuropeptide Y receptors, inhibits gastric motility and increases water and electrolyte absorption in the colon. It is secreted by the gut in response to a meal, and has been shown to reduce appetite.
Relevance to obesity
Leptin also reduces appetite in response to feeding, but obese people develop a resistence to leptin. In contrast, obese people secrete less PYY than normal people do, and in response to added PYY, they reduce their food intake.
- Liu C, Aloia T, Adrian T, Newton T, Bilchik A, Zinner M, Ashley S, McFadden D (1996). Peptide YY: a potential proabsorptive hormone for the treatment of malabsorptive disorders.. Am Surg 62 (3): 232-6. PMID 8607584.
- Batterham RL et al (September 4, 2003). Inhibition of food intake in obese subjects by peptide YY3-36. New England Journal of Medicine 349 (10): 926-928. PMID 12954742.
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