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Oxytocin receptor
Symbol(s) OXTR; OT-R
External IDs OMIM: 167055 MGI109147 Homologene20255
RNA expression pattern


More reference expression data

Human Mouse Entrez 5021 18430 Ensembl ENSG00000180914 ENSMUSG00000049112 Uniprot P30559 Q3UPP9 Refseq NM_000916 (mRNA)
NP_000907 (protein)
XM_001001627 (mRNA)
XP_001001627 (protein)
Location Chr 3: 8.77 - 8.79 Mb Chr 6: 112.44 - 112.46 Mb
Pubmed search [1] [2]

Oxytocin receptors function as inducers of uterine contractions and milk ejection.[1][2] Oxytocin receptors are expressed by the myoepithelial cells of the mammary gland, and in both the myometrium and endometrium of the uterus at the end of pregnancy. In some mammals, oxytocin receptors are also found in the kidney and heart.

The protein encoded by this gene belongs to the G-protein coupled receptor family and acts as a receptor for oxytocin. Its activity is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. The oxytocin-oxytocin receptor system plays an important role in the uterus during parturition.[3]


  1. Gimpl G, Fahrenholz F (2001). The oxytocin receptor system: structure, function, and regulation. Physiol. Rev. 81 (2): 629–83.
  2. Zingg HH, Laporte SA (2003). The oxytocin receptor. Trends Endocrinol. Metab. 14 (5): 222–7.
  3. Entrez Gene: OXTR oxytocin receptor.

External links[]

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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