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A family of proteins of diverse functions in the development of the nervous system. In mammals, they are products of 4 genes, with proteins coded by nrg1 being the most diverse. It influences upregulation of acetylcholine receptor genes beneath the endplate (in this instance known as ARIA = Acetylcholine Receptor Inducing Activity). In development of synapses at the neuromuscular junction, after mammalian motor neurones have made synaptic contact with muscle fibres.


NRG-1,2,3 have been found in fish and birds.

mRNA similar to mammalian Pro-NRG2 precursor hase been found in humus earthworm Lumbricidae.

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