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In parkinsons disease the first prospective randomised double-blind sham-placebo controlled trial of dopamine-producing cell transplants failed to show an improvement in quality of life although some significant clinical improvements were seen in patients below the age of 60. A significant problem was the excess release of dopamine by the transplanted tissue, leading to dystonias. Research in African green monkeys suggests that the use of stem cells might in future provide a similar benefit without inducing dystonias.
- Freed CR, Greene PE, Breeze RE, et al (2001). Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N. Engl. J. Med. 344 (10): 710–9.
- Redmond DE (2002). Cellular replacement therapy for Parkinson's disease--where we are today?. The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry 8 (5): 457–88.
- Redmond E et al (2007). Behavioral improvement in a primate Parkinson's model is associated with multiple homeostatic effects of human neural stem cells. Proceedings of the National Academy of Sciences 104 (29): 12175.