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The correct title of this article is Muscarinic acetylcholine receptor M5. It appears incorrectly here because of technical restrictions.



The human muscarinic acetylcholine receptor M5 which is encoded by the CHRM5 gene is a member of the G protein-coupled receptor superfamily of integral membrane proteins. Binding of the endogenous ligand acetylcholine to the M5 receptor triggers a number cellular responses such as adenylate cyclase inhibition, phosphoinositide degradation, and potassium channel modulation. Muscarinic receptors mediate many of the effects of acetylcholine in the central and peripheral nervous system. The clinical implications of this receptor have not been fully explored; however, stimulation of this receptor is known to increase cyclic AMP levels.[1]

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  • Brann MR, Ellis J, Jørgensen H, et al. (1994). Muscarinic acetylcholine receptor subtypes: localization and structure/function.. Prog. Brain Res. 98: 121–7.
  • Gutkind JS, Novotny EA, Brann MR, Robbins KC (1991). Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.. Proc. Natl. Acad. Sci. U.S.A. 88 (11): 4703–7.
  • Liao CF, Themmen AP, Joho R, et al. (1989). Molecular cloning and expression of a fifth muscarinic acetylcholine receptor.. J. Biol. Chem. 264 (13): 7328–37.
  • Bonner TI, Young AC, Brann MR, Buckley NJ (1990). Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes.. Neuron 1 (5): 403–10.
  • Crespo P, Xu N, Daniotti JL, et al. (1994). Signaling through transforming G protein-coupled receptors in NIH 3T3 cells involves c-Raf activation. Evidence for a protein kinase C-independent pathway.. J. Biol. Chem. 269 (33): 21103–9.
  • Haga K, Kameyama K, Haga T, et al. (1996). Phosphorylation of human m1 muscarinic acetylcholine receptors by G protein-coupled receptor kinase 2 and protein kinase C.. J. Biol. Chem. 271 (5): 2776–82.
  • Kohn EC, Alessandro R, Probst J, et al. (1996). Identification and molecular characterization of a m5 muscarinic receptor in A2058 human melanoma cells. Coupling to inhibition of adenylyl cyclase and stimulation of phospholipase A2.. J. Biol. Chem. 271 (29): 17476–84.
  • Burstein ES, Spalding TA, Brann MR (1998). The second intracellular loop of the m5 muscarinic receptor is the switch which enables G-protein coupling.. J. Biol. Chem. 273 (38): 24322–7.
  • Sato KZ, Fujii T, Watanabe Y, et al. (1999). Diversity of mRNA expression for muscarinic acetylcholine receptor subtypes and neuronal nicotinic acetylcholine receptor subunits in human mononuclear leukocytes and leukemic cell lines.. Neurosci. Lett. 266 (1): 17–20.
  • Wang H, Han H, Zhang L, et al. (2001). Expression of multiple subtypes of muscarinic receptors and cellular distribution in the human heart.. Mol. Pharmacol. 59 (5): 1029–36.
  • Buchli R, Ndoye A, Arredondo J, et al. (2002). Identification and characterization of muscarinic acetylcholine receptor subtypes expressed in human skin melanocytes.. Mol. Cell. Biochem. 228 (1-2): 57–72.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903.
  • Fujii T, Watanabe Y, Inoue T, Kawashima K (2003). Upregulation of mRNA encoding the M5 muscarinic acetylcholine receptor in human T- and B-lymphocytes during immunological responses.. Neurochem. Res. 28 (3-4): 423–9.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). Complete sequencing and characterization of 21,243 full-length human cDNAs.. Nat. Genet. 36 (1): 40–5.
  • De Luca V, Wang H, Squassina A, et al. (2004). Linkage of M5 muscarinic and alpha7-nicotinic receptor genes on 15q13 to schizophrenia.. Neuropsychobiology 50 (2): 124–7.
  • Qu J, Zhou X, Xie R, et al. (2006). The presence of m1 to m5 receptors in human sclera: evidence of the sclera as a potential site of action for muscarinic receptor antagonists.. Curr. Eye Res. 31 (7-8): 587–97.
  • Anney RJ, Lotfi-Miri M, Olsson CA, et al. (2007). Variation in the gene coding for the M5 muscarinic receptor (CHRM5) influences cigarette dose but is not associated with dependence to drugs of addiction: evidence from a prospective population based cohort study of young adults.. BMC Genet. 8: 46.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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