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Motilin receptor
Symbol(s) MLNR; GPR38; MTLR1
External IDs OMIM: 602885 Homologene74398
RNA expression pattern


More reference expression data

Human Mouse Entrez 2862 na Ensembl ENSG00000102539 na Uniprot O43193 na Refseq NM_001507 (mRNA)
NP_001498 (protein)
na (mRNA)
na (protein)
Location Chr 13: 48.69 - 48.69 Mb na
Pubmed search [1] na

Motilin receptor is a G protein-coupled receptor which binds motilin.[1][2] Motilin in turn is an intestinal peptide that stimulates contraction of gut smooth muscle.


  1. Depoortere I (2001). Motilin and motilin receptors: characterization and functional significance. Verh. K. Acad. Geneeskd. Belg. 63 (6): 511–29.
  2. Yang X, Dong L, Yang H (2006). [Evidence for the presence of motilin receptor and a study on the mechanism of motilin induced Ca2+ signaling in rat myenteric neurons]. Sichuan Da Xue Xue Bao Yi Xue Ban 37 (5): 683–6.

Further reading[]

  • Smith RG, Leonard R, Bailey AR, et al. (2001). Growth hormone secretagogue receptor family members and ligands.. Endocrine 14 (1): 9-14.
  • McKee KK, Tan CP, Palyha OC, et al. (1998). Cloning and characterization of two human G protein-coupled receptor genes (GPR38 and GPR39) related to the growth hormone secretagogue and neurotensin receptors.. Genomics 46 (3): 426-34.
  • Feighner SD, Tan CP, McKee KK, et al. (1999). Receptor for motilin identified in the human gastrointestinal system.. Science 284 (5423): 2184-8.
  • Miller P, Roy A, St-Pierre S, et al. (2000). Motilin receptors in the human antrum.. Am. J. Physiol. Gastrointest. Liver Physiol. 278 (1): G18-23.
  • Thielemans L, Depoortere I, Van Assche G, et al. (2001). Demonstration of a functional motilin receptor in TE671 cells from human cerebellum.. Brain Res. 895 (1-2): 119-28.
  • Coulie B, Matsuura B, Dong M, et al. (2001). Identification of peptide ligand-binding domains within the human motilin receptor using photoaffinity labeling.. J. Biol. Chem. 276 (38): 35518-22.
  • Thielemans L, Depoortere I, Vanden Broeck J, Peeters TL (2002). The motilin pharmacophore in CHO cells expressing the human motilin receptor.. Biochem. Biophys. Res. Commun. 293 (4): 1223-7.
  • Depoortere I, Thijs T, Thielemans L, et al. (2003). Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide-6 with the motilin receptor in the rabbit gastric antrum.. J. Pharmacol. Exp. Ther. 305 (2): 660-7.
  • Dunham A, Matthews LH, Burton J, et al. (2004). The DNA sequence and analysis of human chromosome 13.. Nature 428 (6982): 522-8.
  • Matsuura B, Dong M, Naik S, et al. (2006). Differential contributions of motilin receptor extracellular domains for peptide and non-peptidyl agonist binding and activity.. J. Biol. Chem. 281 (18): 12390-6.

External links[]

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