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Lofepramine chemical structure
|ATC code |
|Molecular weight||418.958 g/mol|
|Routes of administration||Oral|
Lofepramine (trademarked Gamanil) is a third generation tricyclic antidepressant used in the treatment of depressive disorders. It has both antidepressant and anxiolytic properties. Lofepramine is metabolized in vivo into desipramine; hence its pharmacological profile is extremely similar.
Indications[edit | edit source]
In the United Kingdom, lofepramine is licensed for the treatment of depression.
Availability[edit | edit source]
In the United Kingdom, lofepramine is marketed generically (as the hydrochloride salt) in the form of 70mg tablets.
Dosage[edit | edit source]
140-210mg daily in divided doses.
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