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inositol 1,4,5-triphosphate receptor, type 1
Symbol(s): ITPR1
Locus: 3 p26.1
EC number [1]
EntrezGene 3708
OMIM 147265
RefSeq NM_002222
UniProt Q14643
inositol 1,4,5-triphosphate receptor, type 2
Symbol(s): ITPR2
Locus: 12 p11.23
EC number [2]
EntrezGene 3709
OMIM 600144
RefSeq NM_002223
UniProt Q14571
inositol 1,4,5-triphosphate receptor, type 3
Symbol(s): ITPR3
Locus: 6 p21.31
EC number [3]
EntrezGene 3710
OMIM 147267
RefSeq NM_002224
UniProt Q14573

Inositol triphosphate receptor (IP3R) is a membrane glycoprotein complex acting as Ca2+ channel activated by inositol triphosphate (IP3).

Distribution[]

It has a broad tissue distribution but is especially abundant in the cerebellum. Most of the IP3R's are found in the cell integrated into the endoplasmic reticulum.

Structure[]

The IP3R complex is formed of four 313 kDa subunits. There are 3 isoforms and these can form homo- or hetero-oligomers.

See also[]

External links[]



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