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Hereditary motor and sensory neuropathies
OMIM [1]
DiseasesDB [2]
MedlinePlus [3]
eMedicine neuro/468
MeSH {{{MeshNumber}}}

Hereditary motor and sensory neuropathies (HMSN) are a group of neuropathies which are characterized by their impact upon both afferent and efferent neural communication.

They are more common than hereditary sensory and autonomic neuropathies.[1]


In 1968, it was classified from groups I to VII:[2][3]

Type Other names Diseases Database OMIM
HMSN1 Charcot–Marie–Tooth disease type 1 5815 (multiple)
HMSN2 Charcot–Marie–Tooth disease type 2 2343 (multiple)
HMSN3 Dejerine–Sottas disease
Charcot–Marie–Tooth disease type 3
5821 145900
HMSN4 Refsum disease 11213 266500
HMSN5 Charcot–Marie–Tooth disease with pyramidal features
HMSN with pyramidal features
HMSN6 Charcot–Marie–Tooth disease type 6
HMSN with optic atrophy
32095 601152
HMSN7 HMSN+retinitis pigmentosa 32094

HMSN is sometimes equated with Charcot-Marie-Tooth disease.[4][5]

See also[]


  1. Houlden H, Blake J, Reilly MM (October 2004). Hereditary sensory neuropathies. Curr. Opin. Neurol. 17 (5): 569–77.
  2. eMedicine - Charcot-Marie-Tooth and Other Hereditary Motor and Sensory Neuropathies : Article by Aamir Hashmat.
  3. Dyck PJ, Lambert EH (June 1968). Lower motor and primary sensory neuron diseases with peroneal muscular atrophy. I. Neurologic, genetic, and electrophysiologic findings in hereditary polyneuropathies. Arch. Neurol. 18 (6): 603–18.
  4. DOI:10.1097/BRS.0b013e3181573d4e
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  5. DOI:10.1097/01.nrl.0000145596.38640.27
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Further reading[]