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Guanylate cyclase (EC 4.6.1.2, also known as guanylyl cyclase or GC) is a lyase enzyme.

Reaction[edit | edit source]

It catalyzes the conversion of guanosine triphosphate (GTP) to 3',5'-cyclic guanosine monophosphate (cGMP) and pyrophosphate:

Types[edit | edit source]

There are soluble and membrane-bound forms of guanylyl cyclases.

Function[edit | edit source]

Once formed, cGMP can be degraded by phosphodiesterases, which themselves are under different forms of regulation, depending on the tissue.

Like cAMP, cGMP is known to regulate many cellular proteins, such as protein kinases, ion channels, and phosphodiesterases.

External links[edit | edit source]


de:Guanylylcyclase

{{enWP| Guanylate cyclase]]

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