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GNAS complex locus
Symbol(s): GNAS GNAS1
Locus: 20 q13.2 -13.3
EC number [1]
EntrezGene 2778
OMIM 139320
RefSeq NM_000516
UniProt Q5JWF2

The Gs alpha subunit (or Gs protein) is a heterotrimeric G protein subunit which activates adenylate cyclase. Researchers have discovered that a change in the location of this protein in the brain could serve as a biomarker for depression, allowing a simple, rapid, laboratory test to identify patients with depression. [1]


Receptors[]

The G-protein coupled receptors that couple to this kind of G-protein are for example:

  • 5-HT receptors type 4 and 7
  • D1-like dopamine receptors
  • β-adrenergic receptors
  • M1 receptor (primarily Gq-coupled)
  • Prostaglandin D2 receptor
  • Adenosine receptor A2a and A2b
  • Calcitonin receptor
  • Calcitonin gene-related peptide receptor

Function[]

Main article: function of cAMP-dependent protein kinase

The general function of Gs is to activate adenylate cyclase, which, in turn, produces cAMP, which, in turn activates cAMP-dependent protein kinase. Further effects of Gs is thus found in function of cAMP-dependent protein kinase.

See also[]

References[]

External links[]


Template:GTPases



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