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Sir Gordon Morgan HolmesCMG, CBE, FRS (22 February 1876 – 29 December 1965) was a British neurologist. He is best known for carrying out pioneering research into the cerebellum and the visual cortex.
He was born in the son of a Louth farmer 40 miles north of Dublin and was educated at Dundalk Academy and Trinity College, Dublin, where he graduated in medicine in 1897.
He was initially employed at Richmond Lunatic Asylum and then, after working his way to New Zealand and back returned to studying neurology in Germany. In 1906 he was appointed Physician to the National Hospital for Nervous Diseases, Queen Square, London.
At the outbreak of WWI he was appointed as consultant neurologist to the British Expeditionary Forces. Working in a field hospital he had a unique opportunity for the investigation of the effects of lesions in specific regions of the brain on balance, vision and bladder function. While in France, Holmes met his future wife, Dr Rosalie Jobson, an Oxford graduate and an international sportswoman, to whom he subsequently proposed marriage while rowing on the Thames. His wartime observations on gunshot wounds re-awakened his interest in cerebellar disease which led to his classical analysis of the symptoms of cerebellar lesions described in his Croonian Lectures to the Royal College of Physicians in 1922.
He was made Companion of the Order of St Michael and St George in 1917, CBE in 1919 and knighted in 1951.
Biography[edit | edit source]
Irish neurologist, born February 22, 1876, Dublin; died December 29, 1965, Farnham, Surrey. Gordon Morgan Holmes' father was a successful farmer at Dellin House, Castlebellingham, County Louth, about 40 miles north of Dublin. The early death of his mother, Kathleen, née Morgan, and his father's remarriage, deeply affected Holmes, and although he had three brothers and three sisters, he was a solitary child. Despite a transient dyslexia, Holmes was a brilliant scholar and after completing his education as a boarder at Dundalk academy, he entered Trinity College, Dublin, and graduated in medicine in 1897, at the age of 21 years.
Holmes was a resident at the Richmond Asylum, but soon after qualification he worked his passage to New Zealand, serving as ship's surgeon. Holmes then undertook 2 1/2 years postgraduate study in neurology in Germany. Initially he was in Berlin, but he said «it was all spoon feeding» and he went to Frankfurt am Main where he worked at the Senckenberg Institute with Ludwig Edinger (1855-1919) and Carl Weigert (1845-1904).
Edinger suggested that he investigated the experimental model of Friedrich Leopold Goltz (1834-1902), which was a dog who had had its brain extirpated, saying «I can’t make anything of it!» It is possible that this experimental animal may have aroused his initial interest in the cerebellum. He said, «I might have become a German» for there was an effort to create a post for him in Frankfurt, but Ehrlich had just commenced his work on Salvarsan and it was decided that the money over the next two years go to that work. Holmes therefore returned to London and became a resident medical officer at the National Hospital for Nervous Diseases in Queen Square, under John Hughlings Jackson (1835-1911), the doyen of British neurologists.
In 1906 Holmes was appointed as director of clinical research at Queen Square, where he commenced collaborating with Henry Head (1861-1940) in 1908. This led to the first accurate account of the functions of the optic thalamus and its relation to the cerebral cortex. The two men complemented one another because Head was imaginative and enthusiastic as well as speculative, whereas Holmes insisted upon attention to detail and would never bend facts to fit a hypothesis. At times this led to clashes between the two, but they continued a close collaboration until the outbreak of the 1st World War.
Holmes retained his urge for adventure and he sought a place on Captain Robert Falcon Scott's (1868-1912) ill-fated expedition to the South Pole. A ruptured Achilles tendon necessitated the abandonment of his plan and Holmes profited from his convalescence by obtaining a higher medical degree. In 1910, having obtained a higher medical degree, Holmes was appointed to the staff of the National Hospital when a senior colleague died suddenly. Thereafter his life revolved around his clinical and teaching activities in this hospital, which were unpaid, and a successful private practice.
Upon the outbreak of World War I Holmes was appointed as consultant neurologist to the British Expeditionary Forces. Working with his neurosurgical colleague Percy Sargent (born 1873) in a field hospital they had set up, he had a unique opportunity for the investigation of the effects of lesions in specific regions of the brain on balance, vision and bladder function. While in France, Holmes met his future wife, Dr Rosalie Jobson, an Oxford graduate and an international sportswoman, to whom he subsequently proposed marriage while rowing on the Thames.
Holmes' observations on gunshot wounds re-awakened his interest in cerebellar disease; this culminated in his classical analysis of the symptoms of cerebellar lesions which were published in his Croonian Lectures to the Royal College of Physicians in 1922, where he added more cases of gunshot wounds to his 1st World War experience as well as patients with cerebellar tumours.
When Holmes returned to the staff of the Charing Cross Hospital after World War I, he was joined by William Adie, a young Australian who became his friend. Holmes and Adie shared interests in neurology and neuroanatomy, and in 1941 they published separate papers on the condition which now bear their conjoined eponym. It seems probable that they had entered into extensive discussion of the disorder which they had documented.
In the period between the wars, Holmes had concurrent appointments at Queen Square, Moorfields Eye Hospital and the Charing Cross Hospital. He was an exceptional teacher of clinical neurology and his weekly case discussions at Queen Square attracted numerous postgraduates.
Holmes disliked medical politics and when forced to be on committees was said to vary between someone who was overwhelmingly bored to being forceful and bullying! He introduced to England the painstaking physical examination of a neurologist and even outstripped Gowers in his systematic collection of clinical data and its correlation with anatomy and pathology.
He investigated amyotonia congenita with James Stanfield Collier (1870-1935) (Brain, London, 1909, 32: 269-284) and described the first removal of a suprarenal tumour (by Percy Sargent) reversing virilism in the patient. He was editor of the journal Brain for many years and was well known for aiding young neurologists by going over their manuscripts and ruthlessly abbreviating and improving the English.
References[edit | edit source]
- PMID 15377710 (PMID 15377710)
- PMID 12870047 (PMID 12870047)
- PMID 4914581 (PMID 4914581)
- PMID 4863052 (PMID 4863052)
- PMID 5332144 (PMID 5332144)
- Gordon Morgan Jones. Who Named It. URL accessed on 20 November 2010.
- Library and Archive Catalogue. Royal Society. URL accessed on 20 November 2010.
Bibliography[edit | edit source]
- Studies in Neurology, 2 volumes. London, H. Frowde, Hodder & Stoughton, 1920 with William Halse Rivers (1864–1922), G. Holmes, James Sherren, Harold Theodore Thompson (1878–1935), George Riddoch (1888–1947):
- The National Hospital 1860–1948. Edinburgh & London, E & S Livingstone Ltd., 1954
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