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materials in their standard state (at 25 °C, 100 kPa)
Infobox disclaimer and references
Glycine (abbreviated as Gly or G) is the organic compound with the formula NH2CH2COOH. It is a [[non-essential amino acid that is an inhibitory neurotransmitterin the spinal cord, binding to receptor sites on alpha motor neurons
It is the smallest of the 20 amino acids commonly found in proteins, coded by codons GGU, GGC, GGA and GGG. Glycine is unique among the proteinogenic amino acids in that it is not chiral. Most proteins contain only small quantities of glycine. A notable exception is collagen, which contains about 35% glycine. In its solid, i.e., crystallized, form, glycine is a free-flowing, sweet-tasting crystalline material.
Etymology[edit | edit source]
Glycine comes from the Greek glykys (sweet) +ine (indicating an organi compound)
Biosynthesis[edit | edit source]
Glycine is not essential to the human diet, since it is biosynthesized in the body from the amino acid serine, which is in turn derived from 3-phosphoglycerate. In most organisms, the enzyme Serine hydroxymethyltransferase catalyses this transformation by removing one carbon atom; pyridoxal phosphate is also necessary:
- Serine + tetrahydrofolate → Glycine + N5,N10-Methylene tetrahydrofolate + H2O
- CO2 + NH4+ + N5,N10-Methylene tetrahydrofolate + NADH + H+ → Glycine + tetrahydrofolate + NAD+
Degradation[edit | edit source]
Glycine is degraded via three pathways. The predominant pathway in animals involves the catalysis of glycine cleavage enzyme, the same enzyme also involved in the biosynthesis of glycine. The degradation pathway is the reverse of this synthetic pathway:
- Glycine + tetrahydrofolate + NAD+ → CO2 + NH4+ + N5,N10-Methylene tetrahydrofolate + NADH + H+
In the second pathway, glycine is degraded in two steps. The first step is the reverse of glycine biosynthesis from serine with serine hydroxymethyl transferase. Serine is then converted to pyruvate by serine dehydratase.
In the third pathway of glycine degradation, glycine is converted to glyoxylate by D-amino acid oxidase. Glycoxylate is then oxidized by hepatic lactate dehydrogenase to oxalate in an NAD+-dependent reaction.
Physiological function[edit | edit source]
As a biosynthetic intermediate[edit | edit source]
Glycine is a building block to numerous natural products. In higher eukaryotes, D-Aminolevulinic acid, the key precursor to porphyrins, is biosynthesized from glycine and succinyl-CoA. Glycine provides the central C2N subunit of all purines.
As a neurotransmitter[edit | edit source]
Glycine is an inhibitory neurotransmitter in the central nervous system, especially in the spinal cord, brainstem, and retina. When glycine receptors are activated, chloride enters the neuron via ionotropic receptors, causing an Inhibitory postsynaptic potential (IPSP). Strychnine is a strong antagonist at ionotropic glycine receptors, whereas bicuculline is a weak one. Glycine is a required co-agonist along with glutamate for NMDA receptors. In contrast to the inhibitory role of glycine in the spinal cord, this behaviour is facilitated at the (NMDA) glutaminergic receptors which are excitatory. The LD50 of glycine is 7930 mg/kg in rats (oral), and it usually causes death by hyperexcitability.
As A Potential Antipsychotic[edit | edit source]
Dr. Daniel Javitt a clinical researcher had studied people who were addicted to PCP (angel dust) and Ketamine (special K) (Javitt, DC, Negative Schizophrenic Symptomatology and the Phencyclydine (PCP) Model of Schizophrenia, Hillside Journal of Psychiatry 1987 9:12-35. Their brains had been damaged by the use of this drug. In studies, it was found that their glutamate receptors had been damaged. Since use of PCP and ketamine creates psychosis similar to schizophrenia, it was hypothesized that giving glycine to people with schizophrenia would potentially reduce their psychotic symptoms. In a controlled study people with schizophrenia who were given glycine had their symptoms measurably reduced primarily in the area of negative and cognitive symptoms when used as an adjunct to current antipsychotics. There have been some psychiatrists who have used it out of study as a primary antipsychotic with benefits on positive as well as negative and cognitive symptoms. Glycine's primary drawback is its required use in powdered format. However, as an NMDA receptor modulator, it is part of a class of antipsychotics in study that do not cause tardive dyskinesia or diabetes, the current long term side effects of dopaminergic antipsychotics as well as not creating extra pyramdial side effects (movement disorders), weight gain or sedation. These medications along with other new classes of medications in study may eventually replace the current antipsychotics which, from Thorazine to Abilify, have all been based on the dopamine hypothesis and in depleting the levels of dopamine. They can create tardive dykinesia and other Parkinsonian movement disorders and potentially tardive psychosis which is still in study. Glycine, is part of a promising new class of treatment for schizophrenia that may promote a full recovery without debilitating physical side effects.
See also[edit | edit source]
References[edit | edit source]
- IUPAC-IUBMB Joint Commission on Biochemical Nomenclature. Nomenclature and Symbolism for Amino Acids and Peptides. Recommendations on Organic & Biochemical Nomenclature, Symbols & Terminology etc. URL accessed on 2007-05-17.
- Nelson, D. L. & Cox, M. M. (2005). Lehninger Principles of Biochemistry, 4th Edition. New York: W. H. Freeman and Company, p. 127. ISBN 0-7167-4339-6.
- Nelson, D. L. & Cox, M. M. (2005). Lehninger Principles of Biochemistry, 4th Edition. New York: W. H. Freeman and Company, p. 844. ISBN 0-7167-4339-6.
- Nelson, D. L. & Cox, M. M. (2005). Lehninger Principles of Biochemistry, 4th Edition. New York: W. H. Freeman and Company, pp. 675-677. ISBN 0-7167-4339-6.
- Nelson, D. L. & Cox, M. M. (2005). Lehninger Principles of Biochemistry, 4th Edition. New York: W. H. Freeman and Company, p. 854. ISBN 0-7167-4339-6.
- Safety (MSDS) data for glycine. The Physical and Theoretical Chemistry Laboratory Oxford University. URL accessed on 2006-11-01.
Further reading[edit | edit source]
- Dawson, R.M.C., Elliott, D.C., Elliott, W.H., and Jones, K.M., Data for Biochemical Research (3rd edition), pp. 1-31 (1986) ISBN 01-985-535-87
[edit | edit source]
- GEO Specialty Chemicals, Inc.
- Computational Chemistry Wiki
- Glycine cleavage system
- Glycine, ChemSub Online
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