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⚫ | In [[biology]] the '''genome''' of an [[organism]] is its whole hereditary information and is encoded in the [[DNA]] (or, for some viruses, [[RNA]]). This includes both the [[gene]]s and the [[Junk DNA|non-coding sequences]] of the DNA. The term was coined in [[1920]] by [[Hans Winkler]], Professor of [[Botany]] at the [[University of Hamburg]], [[Germany]], as a [[portmanteau]] of the words '''''gen'''e'' and ''chromos'''ome'''''. |
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− | {{otheruses}} |
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⚫ | More precisely, the genome of an organism is a complete [[DNA sequence]] of one set of [[chromosome]]s; for example, one of the two sets that a [[diploid]] individual carries in every [[somatic cell]]. The term genome can be applied specifically to mean the complete set of ''[[cell nucleus|nuclear]] DNA'' (i.e., the "nuclear genome") but can also be applied to [[organelles]] that contain their own DNA, as with the [[mitochondrial genome]] or the [[chloroplast]] genome. When people say that the genome of a [[sexual reproduction|sexually reproducing]] [[species]] has been "[[sequencing|sequenced]]," typically they are referring to a determination of the sequences of one set of [[autosome]]s and one of each type of [[sex chromosome]], which together represent both of the possible sexes. Even in species that exist in only one sex, what is described as "a genome sequence" may be a composite from the chromosomes of various individuals. In general use, the phrase "genetic makeup" is sometimes used conversationally to mean the genome of a particular individual or organism. The study of the global properties of genomes of related organisms is usually referred to as [[genomics]], which distinguishes it from [[genetics]] which generally studies the properties of single [[gene]]s or groups of genes. |
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⚫ | In [[biology]] the '''genome''' of an organism is |
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⚫ | |||
⚫ | More precisely, the |
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⚫ | Most biological entities more complex than a [[virus (biology)|virus]] sometimes or always carry additional genetic material besides that which resides in their chromosomes. In some contexts, such as sequencing the genome of a pathogenic microbe, "genome" is meant to include this auxiliary material, which is carried in [[plasmid]]s. In such circumstances then, "genomeey" describes all of the genes and non-coding DNA that have the potential to be present. |
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⚫ | In [[vertebrate]]s such as sheep and other various animals however, "genome" carries the typical connotation of only chromosomal DNA. So although human [[mitochondria]] contain genes, these genes are not considered part of the genome. In fact, mitochondria are sometimes said to have their own genome, often referred to as the "[[mitochondrial genome]]". |
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⚫ | |||
⚫ | Most biological entities more complex than a [[virus (biology)|virus]] sometimes or always carry additional genetic material besides that which resides in their chromosomes. In some contexts, such as sequencing the genome of a pathogenic microbe, "genome" is meant to include this auxiliary material, which is carried in [[plasmid]]s. In such circumstances then, " |
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⚫ | |||
⚫ | In [[vertebrate]]s such as |
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− | |||
⚫ | |||
Note that a genome does not capture the genetic diversity or the genetic [[polymorphism (biology)|polymorphism]] of a species. For example, the human genome sequence in principle could be determined from just half the DNA of one cell from one individual. To learn what variations in DNA underlie particular traits or diseases requires comparisons across individuals. This point explains the common usage of "genome" (which parallels a common usage of "gene") to refer not to any particular DNA sequence, but to a whole family of sequences that share a biological context. |
Note that a genome does not capture the genetic diversity or the genetic [[polymorphism (biology)|polymorphism]] of a species. For example, the human genome sequence in principle could be determined from just half the DNA of one cell from one individual. To learn what variations in DNA underlie particular traits or diseases requires comparisons across individuals. This point explains the common usage of "genome" (which parallels a common usage of "gene") to refer not to any particular DNA sequence, but to a whole family of sequences that share a biological context. |
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Although this concept may seem counter intuitive, it is the same concept that says there is no particular shape that is the shape of a [[cheetah]]. Cheetahs vary, and so do the sequences of their genomes. Yet both the individual animals and their sequences share commonalities, so one can learn something about cheetahs and "cheetah-ness" from a single example of either. |
Although this concept may seem counter intuitive, it is the same concept that says there is no particular shape that is the shape of a [[cheetah]]. Cheetahs vary, and so do the sequences of their genomes. Yet both the individual animals and their sequences share commonalities, so one can learn something about cheetahs and "cheetah-ness" from a single example of either. |
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⚫ | |||
− | ==Minimal genomes== |
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+ | {{details|Genome project}} |
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⚫ | Since genomes and their organisms are very complex, one research strategy is to reduce the number of genes in a genome to the bare minimum and still have the organism in question survive. |
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+ | The [[Human Genome Project]] was organized to [[physical map|map]] and to [[sequencing|sequence]] the human genome. Other genome projects include [[mus musculus|mouse]], [[rice]], the plant ''[[Arabidopsis thaliana]]'', the [[puffer fish]], bacteria like [[E. coli]], etc. In [[1976]], [[Walter Fiers]] at the [[University of Ghent]] ([[Belgium]]) was the first to establish the complete nucleotide sequence of a viral RNA-genome ([[Bacteriophage|bacteriophage MS2]]). The first DNA-genome project to be completed was the [[Phi-X174 phage|Phage Φ-X174]], with only 5368 base pairs, which was sequenced by [[Fred Sanger]] in [[1977]]. The first bacterial genome to be completed was that of [[Haemophilus influenzae]], completed by a team at [[The Institute for Genomic Research]] in 1995. |
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− | ''Main article:'' [[Genome project]] |
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− | The [[Human Genome Project]] was organized to [[physical map|map]] and to [[sequencing|sequence]] the human genome. Other genome projects include [[mus musculus|mouse]], [[rice]], the plant [[Arabidopsis thaliana]], the [[puffer fish]], bacteria like [[E. coli]], etc. |
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+ | {{main|Genome size}} |
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+ | {| class="wikitable" |
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− | ''Compare:'' [[proteome]] |
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− | |||
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+ | |- |
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− | For an updated list of sequenced genomes and their sizes, visit [http://www.cbs.dtu.dk/databases/DOGS/index.php DOGS] |
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+ | |[[Virus]], [[Bacteriophage MS2]] |
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− | <table border=1 cellspacing=0 cellpadding=2> |
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+ | |3569 - First sequenced RNA-genome<ref name=Fiers1976>{{cite journal |author=Fiers W, ''et al.'' |title=Complete nucleotide-sequence of bacteriophage MS2-RNA - primary and secondary structure of replicase gene |journal=Nature |volume=260 |pages=500-507 |year=1976}}</ref> |
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− | <tr> |
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+ | |- |
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⚫ | |||
+ | |[[Virus]], [[SV40]] |
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+ | |5224<ref name=Fiers1978>{{cite journal |author=Fiers W, Contreras R, Haegemann G, Rogiers R, Van de Voorde A, Van Heuverswyn H, Van Herreweghe J, Volckaert G, Ysebaert M |title=Complete nucleotide sequence of SV40 DNA |journal=Nature |volume=273 |issue=5658 |pages=113-120 |year=1978}}</ref> |
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+ | |- |
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− | <tr> |
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− | + | |[[Virus]], [[Phi-X174 phage|Phage Φ-X174;]] |
|
+ | |5386 - First sequenced DNA-genome<ref name=Sanger1977>{{cite journal |author=Sanger F, Air GM, Barrell BG, Brown NL, Coulson AR, Fiddes CA, Hutchison CA, Slocombe PM, Smith M |title=Nucleotide sequence of bacteriophage phi X174 DNA |journal=Nature |volume=265 |issue=5596 |pages=687-695 |year=1977}}</ref> |
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− | <td>5386 - First sequenced genome</td> |
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+ | |- |
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− | </tr> |
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⚫ | |||
− | <tr> |
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⚫ | |||
⚫ | |||
+ | |- |
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− | </tr> |
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+ | |1.6×10<sup>5</sup> - Smallest non-viral genome, Feb 2007 |
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− | <tr> |
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+ | |- |
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+ | |[[Bacterium]], ''[[Buchnera aphidicola]]'' |
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+ | |6×10<sup>5</sup> |
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− | </tr> |
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+ | |- |
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− | <tr> |
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− | + | |[[Bacterium]], ''[[Wigglesworthia glossinidia]]'' |
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− | + | |7×10<sup>5</sup> |
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+ | |- |
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− | </tr> |
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+ | |[[Bacterium]], ''[[Escherichia coli]]'' |
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− | <tr> |
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− | <td>[[Plant]], ''[[Fritillary]] [[Fritillary assyriaca| assyrica]]''</td> |
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+ | |- |
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+ | |[[Amoeba]], ''[[Amoeba dubia]]'' |
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− | </tr> |
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+ | |6.7×10<sup>11</sup> - Largest known genome, Dec 2005 |
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− | <tr> |
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+ | |- |
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+ | |[[Plant]], ''[[Arabidopsis thaliana]]'' |
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+ | |1.2×10<sup>8</sup> - First plant genome sequenced, Dec 2000 |
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− | </tr> |
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+ | |- |
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− | <tr> |
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− | + | |[[Plant]], ''[[Fritillaria assyrica]]'' |
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− | + | |1.3×10<sup>11</sup> |
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+ | |- |
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− | </tr> |
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+ | |[[Plant]], ''[[Poplar|Populus trichocarpa]]'' |
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− | <tr> |
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+ | |4.8×10<sup>8</sup> - First tree genome, Sept 2006 |
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⚫ | |||
+ | |- |
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⚫ | |||
⚫ | |||
− | </tr> |
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− | <tr> |
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+ | |- |
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+ | |[[Nematoda| Nematode]], ''[[Caenorhabditis elegans]]'' |
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+ | |8×10<sup>7</sup> |
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− | </tr> |
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+ | |- |
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− | </table> |
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⚫ | |||
+ | |- |
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+ | |[[Insect]], ''[[Bombyx mori]]'' aka Silk Moth |
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+ | |5.30×10<sup>8</sup> |
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+ | |- |
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+ | |[[Insect]], ''[[Apis mellifera]]'' aka Honey Bee |
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+ | |1.77×10<sup>9</sup> |
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+ | |- |
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⚫ | |||
⚫ | |||
+ | |} |
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''Note:'' The DNA from a single human cell has a length of ~1.8m. |
''Note:'' The DNA from a single human cell has a length of ~1.8m. |
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⚫ | Since genomes and their organisms are very complex, one research strategy is to reduce the number of genes in a genome to the bare minimum and still have the organism in question survive. There is experimental work being done on minimal genomes for single cell organisms as well as minimal genomes for multicellular organisms (see [[Developmental biology]]). The work is both ''[[in vivo]]'' and ''[[in silico]]''. |
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⚫ | |||
+ | |||
⚫ | Genomes are more than the sum of an organism's genes and have traits that may be [[ |
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⚫ | |||
⚫ | Genomes are more than the sum of an organism's genes and have traits that may be [[Measurement|measured]] and studied without reference to the details of any particular genes and their products. Researchers compare traits such as ''chromosome number'' ([[karyotype]]), [[genome size]], [[gene]] order, [[codon usage bias]], and [[GC-content]] to determine what mechanisms could have produced the great variety of genomes that exist today (for recent overviews, see Brown [[2002]]; Saccone and Pesole [[2003]]; Benfey and Protopapas [[2004]]; Gibson and Muse 2004; Reese 2004; Gregory [[2005]]). |
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[[gene duplication|Duplications]] play a major role in shaping the genome. Duplications may range from extension of [[short tandem repeats]], to duplication of a cluster of genes, and all the way to duplications of entire chromosomes or even [[polyploidy|entire genomes]]. Such duplications are probably fundamental to the creation of genetic novelty. |
[[gene duplication|Duplications]] play a major role in shaping the genome. Duplications may range from extension of [[short tandem repeats]], to duplication of a cluster of genes, and all the way to duplications of entire chromosomes or even [[polyploidy|entire genomes]]. Such duplications are probably fundamental to the creation of genetic novelty. |
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− | [[Horizontal gene transfer]] is invoked to explain how there is often extreme similarity between small portions of the genomes of two organisms that are otherwise very distantly related. Horizontal gene transfer seems to be common among many [[microbe]]s. Also, eukaryotic cells seem to have experienced a transfer of some genetic material from their [[chloroplast]] and [[mitochondria]]l genomes to their nuclear chromosomes. |
+ | [[Horizontal gene transfer]] is invoked to explain how there is often extreme similarity between small portions of the genomes of two organisms that are otherwise very distantly related. Horizontal gene transfer seems to be common among many [[microbe]]s. Also, [[Eukaryote |eukaryotic cells]] seem to have experienced a transfer of some genetic material from their [[chloroplast]] and [[mitochondria]]l genomes to their nuclear chromosomes. |
⚫ | |||
− | == Other Omics & Ome pages == |
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+ | *[[gene]] |
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− | * [[Genome]], [[Proteome]], [[Expressome]], [[Metabolome]], [[Regulome]], [[Functome]], [[Phenome]], [[Textome]] |
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+ | *[[gene family]] |
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− | * [[Mitochondriomics]], [[Golgiome]], [[Ligandomics]], [[Eukaryome]], [[Bacteriome]], [[Archaeome]] |
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+ | *[[Genome Comparison]] |
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− | |||
− | + | *[[Genome project]] |
|
− | * |
+ | *[[Human genome]] |
+ | *[[List of omics topics in biology]] |
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+ | *[[List of sequenced eukaryotic genomes]] |
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+ | *[[List of sequenced prokaryotic genomes]] |
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+ | *[[List of sequenced archeal genomes]] |
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+ | *[[Mitochondrial genome]] |
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+ | *[[molecular systematics]] |
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+ | *[[molecular evolution]] |
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+ | *[[Honey Bee Genome Sequencing Consortium]] |
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==References== |
==References== |
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+ | <!-- ---------------------------------------------------------- |
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− | |||
+ | See http://en.wikipedia.org/wiki/Wikipedia:Footnotes for a |
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+ | discussion of different citation methods and how to generate |
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− | |||
+ | footnotes using the <ref>, </ref> and <reference /> tags |
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+ | ----------------------------------------------------------- --> |
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− | |||
+ | <div class="references-small"> |
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− | Gibson, G and Muse, SV (2004). A Primer of Genome Science (Second Edition). Sinauer Assoc. |
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+ | <references /> |
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− | |||
⚫ | |||
⚫ | |||
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− | |||
− | + | * Gibson, G and Muse, SV (2004). A Primer of Genome Science (Second Edition). Sinauer Assoc. |
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⚫ | |||
− | |||
− | + | * Reece, RJ (2004). Analysis of Genes and Genomes. John Wiley & Sons. |
|
+ | * Saccone, C and Pesole, G (2003). Handbook of Comparative Genomics. John Wiley & Sons. |
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− | |||
+ | * Werner, E. In silico multicellular systems biology and minimal genomes, Drug Discov Today. 2003 Dec 15;8(24):1121-7. [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=14678738&query_hl=3 PubMed] |
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− | *[[Developmental biology]], [[evolution]], [[molecular systematics]], [[molecular evolution]], [[gene family]], [[gene]] |
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== External links == |
== External links == |
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+ | * [http://www.dnai.org/ DNA Interactive: The History of DNA Science] |
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+ | * [http://www.dnaftb.org/ DNA From The Beginning] |
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+ | * [http://www.genome.gov/10001772 All About The Human Genome Project from Genome.gov] |
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⚫ | |||
⚫ | |||
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+ | * [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=genomeprj NCBI Entrez Genome Project database] |
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+ | * [http://www.ncbi.nlm.nih.gov/About/primer/genetics_genome.html NCBI Genome Primer] |
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+ | * [http://news.bbc.co.uk/1/hi/sci/tech/4994088.stm BBC News - Final genome 'chapter' published] |
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+ | * [http://www.skyjuicesoftware.com/3models/?wiki Software that maps an Artificial Genome sequence to a Network and to a Lineage tree] |
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+ | * [http://img.jgi.doe.gov/ IMG] The Integrated Microbial Genomes system, for genome analysis by the DOE-JGI. |
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+ | <!-- |
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+ | [[eo:Genomo]] |
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[[fr:Génome]] |
[[fr:Génome]] |
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[[ko:게놈]] |
[[ko:게놈]] |
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+ | [[id:Genom]] |
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[[ia:Genoma]] |
[[ia:Genoma]] |
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[[it:Genoma]] |
[[it:Genoma]] |
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[[he:גנום]] |
[[he:גנום]] |
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+ | [[lb:Genom]] |
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[[hu:Genom]] |
[[hu:Genom]] |
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[[nl:Genoom]] |
[[nl:Genoom]] |
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[[ja:ゲノム]] |
[[ja:ゲノム]] |
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+ | [[no:Genom]] |
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[[pl:Genom]] |
[[pl:Genom]] |
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[[pt:Genoma]] |
[[pt:Genoma]] |
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+ | [[ro:Genom]] |
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[[ru:Геном]] |
[[ru:Геном]] |
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+ | [[sk:Genóm]] |
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+ | [[fi:Genomi]] |
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[[sv:Genom]] |
[[sv:Genom]] |
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+ | [[vi:Bộ gene]] |
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[[tr:Genom]] |
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[[zh:基因組]] |
[[zh:基因組]] |
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+ | --> |
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{{enWP|Genome}} |
{{enWP|Genome}} |
Revision as of 21:21, 6 March 2007
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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
In biology the genome of an organism is its whole hereditary information and is encoded in the DNA (or, for some viruses, RNA). This includes both the genes and the non-coding sequences of the DNA. The term was coined in 1920 by Hans Winkler, Professor of Botany at the University of Hamburg, Germany, as a portmanteau of the words gene and chromosome.
More precisely, the genome of an organism is a complete DNA sequence of one set of chromosomes; for example, one of the two sets that a diploid individual carries in every somatic cell. The term genome can be applied specifically to mean the complete set of nuclear DNA (i.e., the "nuclear genome") but can also be applied to organelles that contain their own DNA, as with the mitochondrial genome or the chloroplast genome. When people say that the genome of a sexually reproducing species has been "sequenced," typically they are referring to a determination of the sequences of one set of autosomes and one of each type of sex chromosome, which together represent both of the possible sexes. Even in species that exist in only one sex, what is described as "a genome sequence" may be a composite from the chromosomes of various individuals. In general use, the phrase "genetic makeup" is sometimes used conversationally to mean the genome of a particular individual or organism. The study of the global properties of genomes of related organisms is usually referred to as genomics, which distinguishes it from genetics which generally studies the properties of single genes or groups of genes.
Types
Most biological entities more complex than a virus sometimes or always carry additional genetic material besides that which resides in their chromosomes. In some contexts, such as sequencing the genome of a pathogenic microbe, "genome" is meant to include this auxiliary material, which is carried in plasmids. In such circumstances then, "genomeey" describes all of the genes and non-coding DNA that have the potential to be present.
In vertebrates such as sheep and other various animals however, "genome" carries the typical connotation of only chromosomal DNA. So although human mitochondria contain genes, these genes are not considered part of the genome. In fact, mitochondria are sometimes said to have their own genome, often referred to as the "mitochondrial genome".
Genomes and genetic variation
Note that a genome does not capture the genetic diversity or the genetic polymorphism of a species. For example, the human genome sequence in principle could be determined from just half the DNA of one cell from one individual. To learn what variations in DNA underlie particular traits or diseases requires comparisons across individuals. This point explains the common usage of "genome" (which parallels a common usage of "gene") to refer not to any particular DNA sequence, but to a whole family of sequences that share a biological context.
Although this concept may seem counter intuitive, it is the same concept that says there is no particular shape that is the shape of a cheetah. Cheetahs vary, and so do the sequences of their genomes. Yet both the individual animals and their sequences share commonalities, so one can learn something about cheetahs and "cheetah-ness" from a single example of either.
Genome projects
- For more details on this topic, see Genome project.
The Human Genome Project was organized to map and to sequence the human genome. Other genome projects include mouse, rice, the plant Arabidopsis thaliana, the puffer fish, bacteria like E. coli, etc. In 1976, Walter Fiers at the University of Ghent (Belgium) was the first to establish the complete nucleotide sequence of a viral RNA-genome (bacteriophage MS2). The first DNA-genome project to be completed was the Phage Φ-X174, with only 5368 base pairs, which was sequenced by Fred Sanger in 1977. The first bacterial genome to be completed was that of Haemophilus influenzae, completed by a team at The Institute for Genomic Research in 1995. Many genomes have been sequenced by various genome projects. The cost of sequencing continues to drop, and it is possible that eventually an individual human genome could be sequenced for around several thousand dollars (US).
Comparison of different genome sizes
- Main article: Genome size
Organism | Genome size (base pairs) |
---|---|
Virus, Bacteriophage MS2 | 3569 - First sequenced RNA-genome[1] |
Virus, SV40 | 5224[2] |
Virus, Phage Φ-X174; | 5386 - First sequenced DNA-genome[3] |
Virus, Phage λ | 5×104 |
Bacterium, Carsonella ruddii | 1.6×105 - Smallest non-viral genome, Feb 2007 |
Bacterium, Buchnera aphidicola | 6×105 |
Bacterium, Wigglesworthia glossinidia | 7×105 |
Bacterium, Escherichia coli | 4×106 |
Amoeba, Amoeba dubia | 6.7×1011 - Largest known genome, Dec 2005 |
Plant, Arabidopsis thaliana | 1.2×108 - First plant genome sequenced, Dec 2000 |
Plant, Fritillaria assyrica | 1.3×1011 |
Plant, Populus trichocarpa | 4.8×108 - First tree genome, Sept 2006 |
Fungus,Saccharomyces cerevisiae | 2×107 |
Nematode, Caenorhabditis elegans | 8×107 |
Insect, Drosophila melanogaster aka Fruit Fly | 1.3×108 |
Insect, Bombyx mori aka Silk Moth | 5.30×108 |
Insect, Apis mellifera aka Honey Bee | 1.77×109 |
Mammal, Homo sapiens | 3×109 |
Note: The DNA from a single human cell has a length of ~1.8m.
Since genomes and their organisms are very complex, one research strategy is to reduce the number of genes in a genome to the bare minimum and still have the organism in question survive. There is experimental work being done on minimal genomes for single cell organisms as well as minimal genomes for multicellular organisms (see Developmental biology). The work is both in vivo and in silico.
Genome evolution
Genomes are more than the sum of an organism's genes and have traits that may be measured and studied without reference to the details of any particular genes and their products. Researchers compare traits such as chromosome number (karyotype), genome size, gene order, codon usage bias, and GC-content to determine what mechanisms could have produced the great variety of genomes that exist today (for recent overviews, see Brown 2002; Saccone and Pesole 2003; Benfey and Protopapas 2004; Gibson and Muse 2004; Reese 2004; Gregory 2005).
Duplications play a major role in shaping the genome. Duplications may range from extension of short tandem repeats, to duplication of a cluster of genes, and all the way to duplications of entire chromosomes or even entire genomes. Such duplications are probably fundamental to the creation of genetic novelty.
Horizontal gene transfer is invoked to explain how there is often extreme similarity between small portions of the genomes of two organisms that are otherwise very distantly related. Horizontal gene transfer seems to be common among many microbes. Also, eukaryotic cells seem to have experienced a transfer of some genetic material from their chloroplast and mitochondrial genomes to their nuclear chromosomes.
See also
- gene
- gene family
- Genome Comparison
- Genome project
- Human genome
- List of omics topics in biology
- List of sequenced eukaryotic genomes
- List of sequenced prokaryotic genomes
- List of sequenced archeal genomes
- Mitochondrial genome
- molecular systematics
- molecular evolution
- Honey Bee Genome Sequencing Consortium
References
- ↑ Fiers W, et al. (1976). Complete nucleotide-sequence of bacteriophage MS2-RNA - primary and secondary structure of replicase gene. Nature 260: 500-507.
- ↑ Fiers W, Contreras R, Haegemann G, Rogiers R, Van de Voorde A, Van Heuverswyn H, Van Herreweghe J, Volckaert G, Ysebaert M (1978). Complete nucleotide sequence of SV40 DNA. Nature 273 (5658): 113-120.
- ↑ Sanger F, Air GM, Barrell BG, Brown NL, Coulson AR, Fiddes CA, Hutchison CA, Slocombe PM, Smith M (1977). Nucleotide sequence of bacteriophage phi X174 DNA. Nature 265 (5596): 687-695.
- Benfey, P and Protopapas, AD (2004). Essentials of Genomics. Prentice Hall.
- Brown, TA (2002). Genomes 2. Bios Scientific Publishers.
- Gibson, G and Muse, SV (2004). A Primer of Genome Science (Second Edition). Sinauer Assoc.
- Gregory, TR (ed) (2005). The Evolution of the Genome. Elsevier.
- Reece, RJ (2004). Analysis of Genes and Genomes. John Wiley & Sons.
- Saccone, C and Pesole, G (2003). Handbook of Comparative Genomics. John Wiley & Sons.
- Werner, E. In silico multicellular systems biology and minimal genomes, Drug Discov Today. 2003 Dec 15;8(24):1121-7. PubMed
External links
- DNA Interactive: The History of DNA Science
- DNA From The Beginning
- All About The Human Genome Project from Genome.gov
- Animal genome size database
- Plant genome size database
- GOLD:Genomes OnLine Database
- The Genome News Network
- NCBI Entrez Genome Project database
- NCBI Genome Primer
- BBC News - Final genome 'chapter' published
- Software that maps an Artificial Genome sequence to a Network and to a Lineage tree
- IMG The Integrated Microbial Genomes system, for genome analysis by the DOE-JGI.
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