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in: Pages with broken file links, Glycolysis, Enzymes

Aldolase A

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Assessment | Biopsychology | Comparative | Cognitive | Developmental | Language | Individual differences | Personality | Philosophy | Social |
Methods | Statistics | Clinical | Educational | Industrial | Professional items | World psychology |

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)

Aldolase A
File:Fructose-1,6-bisphosphate aldolase 4ALD wpmp.png
Enzyme Fructose 1,6-bisphosphate aldolase
PDB Code PDB 4ALD
Organism Human
Tissue Muscle
Complexed molecules fructose 1,6-bisphosphate

Aldolase A is an enzyme which catalyses one of the aldol reactions: The substrate, fructose 1,6-bisphosphate (F-1,6-BP) is broken down into glyceraldehyde 3-phosphate and dihydroxyacetone phosphate (DHAP). This reaction is a part of glycolysis.

β-D-fructose 1,6-phosphate fructose bisphosphate aldolase D-glyceraldehyde 3-phosphate dihydroxyacetone phosphate
image:beta-D-fructose-1,6-bisphosphate_wpmp image:D-glyceraldehyde-3-phosphate_wpmp + image:glycerone-phosphate_wpmp
image:Biochem_reaction_arrow_reversible_NNNN_horiz_med
fructose bisphosphate aldolase

Compound C05378 at KEGG Pathway Database. 

Enzyme 4.1.2.13 at KEGG Pathway Database.
Compound C00111 at KEGG Pathway Database.
Compound C00118 at KEGG Pathway Database.


The numbering of the carbon atoms indicates the fate of the carbons according to their position in fructose 6-phosphate.

Mechanism[]

In mammalian aldolase the key catylitic amino acid residues involved in the reaction are lysine and tyrosine. The tyrosine acts as an efficient hydrogen acceptor while the lysine covalently binds and stabilizes the intermediates. Many bacteria use two magnesium ions in place of the lysine.

ALDO reaction

The reaction mechanism of aldolase.
The enzyme's reactive site amino acid's side chains are shown in blue.
Abbreviations: DHAP - dihydroxyacetone phosphate; Fru1,6bP - Fructose-1,6-bisphosphate; GAD - glyceraldehyde 3-phosphate;

External links[]

Glucose wpmp This metabolism related enzyme article is a stub. You can help Wikipedia by expanding it

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Glycolysis Metabolic Pathway
Glucose Glucose-6-phosphate Fructose 6-phosphate Fructose 1,6-bisphosphate Dihydroxyacetone phosphate Glyceraldehyde 3-phosphate Glyceraldehyde 3-phosphate
D-glucose wpmp ATP ADP Alpha-D-glucose-6-phosphate wpmp Beta-D-fructose-6-phosphate wpmp ATP ADP Beta-D-fructose-1,6-bisphosphate wpmp Glycerone-phosphate wpmp D-glyceraldehyde-3-phosphate wpmp D-glyceraldehyde-3-phosphate wpmp NAD+ + Pi NADH + H+
Biochem reaction arrow foward YYNN horiz med Biochem reaction arrow reversible NNNN horiz med Biochem reaction arrow foward YYNN horiz med Biochem reaction arrow reversible NNNN horiz med + Biochem reaction arrow reversible NNNN horiz med 2 Biochem reaction arrow reversible YYYY horiz med
NAD+ + Pi NADH + H+
1,3-Bisphosphoglycerate 3-Phosphoglycerate 2-Phosphoglycerate Phosphoenolpyruvate Pyruvate Acetyl-CoA
1,3-bisphospho-D-glycerate wpmp ADP ATP 3-phospho-D-glycerate wpmp 2-phospho-D-glycerate wpmp H2O Phosphoenolpyruvate wpmp ADP ATP Pyruvate wpmp CoA + NAD+ NADH + H+ + CO2 Acetyl co-A wpmp
2 Biochem reaction arrow reversible YYYY horiz med 2 Biochem reaction arrow reversible NNNN horiz med 2 Biochem reaction arrow reversible NYYN horiz med 2 Biochem reaction arrow foward YYNN horiz med 2 Biochem reaction arrow foward YYNN horiz med 2
ADP ATP H2O


v·d·e
Carbon-carbon lyases (EC 4.1)
4.1.1: Carboxy-lyases

Pyruvate decarboxylase -Oxaloacetate decarboxylase - Acetoacetate decarboxylase - Malonyl-CoA decarboxylase - Glutamate decarboxylase - Ornithine decarboxylase - Lysine decarboxylase - Phosphoribosylaminoimidazole carboxylase - Histidine decarboxylase - Uridine monophosphate synthetase/Orotidine 5'-phosphate decarboxylase - Aromatic L-amino acid decarboxylase - Phosphoenolpyruvate carboxylase - Pyrophosphomevalonate decarboxylase - Uroporphyrinogen III decarboxylase - RuBisCO - Phosphoenolpyruvate carboxykinase - Adenosylmethionine decarboxylase

4.1.2: Aldehyde-lyases

Aldolase A/Aldolase B - 2-hydroxyphytanoyl-CoA lyase

4.1.3: Oxo-acid-lyases

3-hydroxy-3-methylglutaryl-CoA lyase


v·d·e
Carbohydrate metabolism: glycolysis/gluconeogenesis enzymes
Glycolysis

Glucokinase/Hexokinase/Glucose 6-phosphatase - Glucose isomerase - Phosphofructokinase 1/Fructose 1,6-bisphosphatase - Aldolase - Triosephosphate isomerase - Glyceraldehyde 3-phosphate dehydrogenase - Phosphoglycerate kinase - Phosphoglycerate mutase - Enolase - Pyruvate kinase

Gluconeogenesis only

Pyruvate carboxylase - Phosphoenolpyruvate carboxykinase - from lactate (Cori cycle): Lactate dehydrogenase - from alanine (Alanine cycle): Alanine transaminase

Regulatory

Phosphofructokinase 2/Fructose 2,6-bisphosphatase - Bisphosphoglycerate mutase

de:Aldolase
pl:Aldolazy
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