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A fatty-acid metabolism disorder is a defect in one of the enzymes involved in fatty acid metabolism.
They are sometimes classified with the lipid metabolism disorders, but in other contexts they are considered a distinct category.
In addition to the fetal complications, they can also cause complications for the mother during pregnancy.
The fatty acids are transported by carnitine, and defects in this process are associated with several disorders. They involve the step immediately before oxidation, and are often grouped with the oxidation disorders.
- Lipid Metabolism: Hereditary Metabolic Disorders: Merck Manual Home Edition. URL accessed on 2009-03-11.
- Shekhawat PS, Matern D, Strauss AW (May 2005). Fetal fatty acid oxidation disorders, their effect on maternal health and neonatal outcome: impact of expanded newborn screening on their diagnosis and management. Pediatr. Res. 57 (5 Pt 2): 78R–86R.
- Ibdah JA, Bennett MJ, Rinaldo P, et al (June 1999). A fetal fatty-acid oxidation disorder as a cause of liver disease in pregnant women. N. Engl. J. Med. 340 (22): 1723–31.
- Fatty Acid and Glycerol Metabolism Disorders: Inherited Disorders of Metabolism: Merck Manual Professional. URL accessed on 2009-03-11.
- Longo N, Amat di San Filippo C, Pasquali M (May 2006). Disorders of carnitine transport and the carnitine cycle. Am J Med Genet C Semin Med Genet 142C (2): 77–85.
Template:Fatty-acid metabolism disorders
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