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Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
Estrone chemical structure | |
3-hydroxy-13-methyl- 6,7,8,9,11,12,13,14,15,16- decahydrocyclopenta[a]phenanthren- 17- one IUPAC name | |
CAS number 53-16-7 |
ATC code G03CA07 . |
PubChem 5870 |
DrugBank APRD00588 |
Chemical formula | {{{chemical_formula}}} |
Molecular weight | 270.366 g/mol |
Bioavailability | |
Metabolism | |
Elimination half-life | 19 hours |
Excretion | |
Pregnancy category | |
Legal status | |
Routes of administration |
Estrone (also oestrone) is an estrogenic hormone secreted by the ovary as well as adipose.
Estrone is one of the three estrogens, which also include estriol and estradiol. Estrone is the least abundant of the three hormones, estradiol is present almost always in the reproductive female body, and estriol is abundant primarily during pregnancy.
Estrone is relevant to health and disease states because of its conversion to estrone sulfate, a long-lived derivative. Estrone sulfate acts as a reservoir that can be converted as needed to the more active estradiol.
Estrone is the only one of the three estrogens which is present in any quantity in post-menopausal women.
Synthesis[]
Estrone is synthesized via aromatase from androstenedione, a derivative of progesterone. The conversion consists of the de-methylation of C-19 and the aromaticity of the 'A' ring. This reaction is similar to the conversion of testosterone to estradiol.
Additional images[]
Sex hormones and related agents (primarily G03, also L02, H01C) - human endogenous in CAPS
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Progestogens: (receptor) |
PROGESTERONE, Desogestrel, Drospirenone, Dydrogesterone, Ethisterone, Etonogestrel, Ethynodiol diacetate, Gestodene, Gestonorone, Levonorgestrel, Lynestrenol, Medroxyprogesterone, Megestrol, Norelgestromin,
Norethisterone, Norethynodrel, Norgestimate, Norgestrel, Norgestrienone, Tibolone |
Androgens: (receptor) |
TESTOSTERONE, Androstanolone, Fluoxymesterone, Mesterolone, Methyltestosterone, (see also anabolic steroids) Antiandrogens: Bicalutamide, Cyproterone, Flutamide, Nilutamide, Spironolactone |
Estrogens: (receptor) |
ESTRADIOL, ESTRIOL, ESTRONE, Chlorotrianisene, Dienestrol, Diethylstilbestrol, Ethinylestradiol, Fosfestrol, Mestranol, Polyestradiol phosphate Selective estrogen receptor modulator: Bazedoxifene, Clomifene, Fulvestrant, Raloxifene, Tamoxifen, Toremifene Aromatase inhibitor: Aminogluthetimide, Anastrozole, Exemestane, Formestane, Letrozole, Vorozole |
Gonadotropins: (FSHR/LHCGR) |
ovulation stim.: Clomifene, Urofollitropin Antigonadotropins: Danazol, Gestrinone |
GnRH: (receptor) |
agonist: Buserelin, Goserelin, Histrelin, Leuprorelin, Nafarelin, Triptorelin antagonist: Abarelix, Cetrorelix, Ganirelix |
Template:Cholesterol and steroid intermediates
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