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The diathesis-stress model is a psychological theory that explains behavior as both a result of biological and genetic factors ("nature"), and life experiences ("nurture").Diathesis is the heriditary predispostion to a disorder (from the Greek diathesis=arrangement, from dia=asunder+tithenai=to place).Stress is the environmental load put on the organism.

This theory is often used to describe the pronunciation of mental disorders, like schizophrenia, that are produced by the interaction of a vulnerable hereditary predisposition, with precipitating events in the environment. This theory was originally introduced as a means to explain some of the underlying causes of schizophrenia (Zubin & Spring, 1977).

In the diathesis-stress model, a genetic vulnerability or predisposition (diathesis) interacts with the environment and life events (stressors) to trigger behaviours or psychological disorders. The greater the * Gene-environment interaction

The diathesis-stress model has been reformulated in the last 20 years as the stress-vulnerability-protective factors model, particularly by Dr. Robert P. Liberman and his colleagues in the field of psychiatric rehabilitation. This model has had profound benefits for people with severe and persistent mental illnesses. It has stimulated research on the common stressors that people with disorders such as schizophrenia experience. More importantly, it has stimulated research and treatment on how to mitigate this stress, and therefore reduce the expression of the diathesis, by developing protective factors. Protective factors include rigorous and nuanced psychopharmacology, skill building (especially problem solving and basic communication skills) and the development of support systems for individuals with these illnesses. Even more importantly, the stress-vulnerability-protective factors model has allowed mental health workers, family members, and clients to create a sophisticated personal profile of what happens when the person is doing poorly (the diathesis), what hurts (the stressors), and what helps (the protective factors). This has resulted in more humane, effective, efficient, and empowering treatment interventions

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  • Zubin, J. & Spring, B. (1977). Vulnerability: A new view of schizophrenia. Journal of Abnormal Psychology, 86, 103-126.

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