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Desipramine chemical structure
|10, 11-dihydro-5-[3-(methylamino) propyl]-5H-dibenz[b,f]azepine monohydrochloride|
|ATC code |
|Elimination half-life||21-23 hours|
|Legal status||Rx only|
|Routes of administration||oral|
Desipramine is a tricyclic antidepressant (TCA) that inhibits the reuptake of norepinephrine. It is sold under the brand names Norpramin and Pertofrane. It is used to treat depression, but not considered a first line treatment since the introduction of SSRI antidepressants. Desipramine is an active metabolite of imipramine.
Along with other tricyclics, desipramine has found use in treating neuropathic pain. The mechanism of action seems to involve the activation, through norepinephrine reuptake inhibition, of descending pathways in the spinal cord that block pain signals from ascending to the brain. Desipramine is one of the most potent and selective medications in this respect. It may also be used to treat symptoms of Attention Deficit Disorder, as the underproduction of norepinephrine has been increasingly linked to symptoms associated with Attention Deficit Disorder.
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- British Journal of Cancer 2002: volume 86, pages 92-97