Clorazepate chemical structure
|ATC code |
|Elimination half-life||48 hours|
|Legal status||Schedule IV(US)|
|Routes of administration||Oral|
Clorazepate (marketed under the brand names Tranxene and Novo-Clopate), also known as clorazepate dipotassium, is a drug which is a benzodiazepine derivative. It possesses anxiolytic, anticonvulsant, sedative, hypnotic and skeletal muscle relaxant properties. Clorazepate was discontinued in February 2006 in the United Kingdom. Clorazepate is a prodrug for desmethyldiazepam which is rapidly produced as an active metabolite. Desmethyldiazepam is responsible for most of the therapeutic effects of clorazepate.
Indications[edit | edit source]
Clorazepate is principally prescribed in the treatment of alcohol withdrawal and epilepsy, although it is also a useful anxiolytic because of its long half-life. The normal starting dosage range of Clorazepate is 15 to 60 mg per day. The drug is to be taken two to four times per day. Dosages as high as 90 to 120 mg per day may be used in the treatment of acute alcohol withdrawal. In the United States and Canada, Clorazepate is available in 3.75, 7.5, and 15 mg capsules or tablets. In Europe, tablet formations are 5 mg, 10 mg, 20 mg and 50 mg. Clorazepate SD (controlled release) is available in 11.25 and 22.5 mg tablets. Clorazepate SD is only prescribed when the patient has become adjusted to a certain dosage, and is taken once a day. Clorazepate is available in generic form. Clorazepate begins to act on the central nervous system within one or two hours, and its effects may be felt for an entire day or longer in some individuals. It is contraindicated for those with impaired renal or hepatic function.
Pharmacology[edit | edit source]
Clorazepate is a "classical" benzodiazepine. Other classical benzodiazepines include alprazolam, diazepam, clonazepam, oxazepam, lorazepam, nitrazepam, bromazepam and flurazepam. Clorazepate is a long acting benzodiazepine drug. Clorazepate produces the metabolite desmethyl-diazepam which has a half life of 36 – 200 hours.
Interactions[edit | edit source]
All sedatives or hypnotics eg other benzodiazepines, alcohol, antihistamines, opiates, neuroleptics, sleep aids are likely to magnify the effects of clorazepate on the central nervous system. Drugs which may interact with clorazepate include, digoxin, disulfiram, fluoxetine, isoniazid, ketoconazole, levodopa, metoprolol, hormonal contraceptives, probenecid, rifampin, theophylline, valproic acid.
Tolerance, dependence and withdrawal[edit | edit source]
- Main article: Benzodiazepine withdrawal syndrome
In humans tolerance to the anticonvulsant effects of clorazepate occurs frequently with regular use. However, tolerance to the active metabolite of clorazepate may occur more slowly than with other benzodiazepines. Regular use of benzodiazepines causes the development of dependence characterised by tolerance to the therapeutic effects of benzodiazepines and the development of the benzodiazepine withdrawal syndrome including symptoms such as anxiety, apprehension, tremor, insomnia, nausea, and vomiting upon cessation of benzodiazepine use. Withdrawal from benzodiazepines should be gradual as abrupt withdrawal from high doses of benzodiazepines may cause confusion, toxic psychosis, convulsions, or a condition resembling delirium tremens. Abrupt withdrawal from lower doses may cause depression, nervousness, rebound insomnia, irritability, sweating, and diarrhoea.
Contraindications and special caution[edit | edit source]
Chlorazepate if used late in pregnancy, the third trimester, causes a definite risk a severe benzodiazepine withdrawal syndrome in the neonate with symptoms including hypotonia, and reluctance to suck, to apnoeic spells, cyanosis, and impaired metabolic responses to cold stress. Floppy infant syndrome and sedation in the new born may also occur. Symptoms of floppy infant syndrome and the neonatal benzodiazepine withdrawal syndrome have been reported to persist from hours to months after birth.
Legal status[edit | edit source]
See also[edit | edit source]
- Benzodiazepine dependence
- Benzodiazepine withdrawal syndrome
- Long term effects of benzodiazepines
References[edit | edit source]
- National electronic Library for Medicines. SPC (Product Licence) Changes. E-Communications Team at the London and South East Medicines Information Service based at Guy’s Hospital London. URL accessed on 19 December 2008.
- Ochs HR, Greenblatt DJ, Verburg-Ochs B, Locniskar A (October 1984). Comparative single-dose kinetics of oxazolam, prazepam, and clorazepate: three precursors of desmethyldiazepam. J Clin Pharmacol 24 (10): 446–51.
- National Institutes of Health (2003). Clorazepate. National Library of Medicine. URL accessed on 19 July 2008.
- Tranxene prescribing information in the Netherlands (Dutch language); accessed 2007-03-08
- Braestrup C, Squires RF. (1 April 1978). Pharmacological characterization of benzodiazepine receptors in the brain. Eur J Pharmacol 48 (3): 263–70.
- The Committee on the Review of Medicines (CRM) (March 29, 1980). Systematic review of the benzodiazepines. Guidelines for data sheets on diazepam, chlordiazepoxide, medazepam, clorazepate, lorazepam, oxazepam, temazepam, triazolam, nitrazepam, and flurazepam. Committee on the Review of Medicines. Br Med J. 280 (6218): 910–2.
- Professor heather Ashton (2007). BENZODIAZEPINE EQUIVALENCY TABLE. URL accessed on September 23, 2007.
- Divoll M, Greenblatt DJ, Abernethy DR, Shader RI (November 1982). Cimetidine impairs clearance of antipyrine and desmethyldiazepam in the elderly. J Am Geriatr Soc 30 (11): 684–9.
- Loiseau P (1983). [Benzodiazepines in the treatment of epilepsy]. Encephale 9 (4 Suppl 2): 287B–292B.
- (Aug 2008). Benzodiazepines in epilepsy: pharmacology and pharmacokinetics.. Acta Neurol Scand 118 (2): 69-86.
- Committee on the Review of Medicines (March 29, 1980). Systematic review of the benzodiazepines. Guidelines for data sheets on diazepam, chlordiazepoxide, medazepam, clorazepate, lorazepam, oxazepam, temazepam, triazolam, nitrazepam, and flurazepam. Committee on the Review of Medicines. Br Med J. 280 (6218): 910–2.
- (November 2009). Benzodiazepine dependence: focus on withdrawal syndrome.. Ann Pharm Fr 67 (6): 408–13.
- McElhatton PR. (Nov-December 1994). The effects of benzodiazepine use during pregnancy and lactation. Reprod Toxicol. 8 (6): 461–75.
[edit | edit source]
Benzodiazepines (N05BA, N05CD)
Bromazepam • Camazepam • Carburazepam • Chlordiazepoxide • Cinolazepam • Clonazepam • Clorazepate • Cyprazepam • Delorazepam • Demoxepam • Diazepam • Doxefazepam • Elfazepam • Ethyl carfluzepate • Ethyl dirazepate • Ethyl loflazepate • Fletazepam • Fludiazepam • Flunitrazepam • Flurazepam • Flutemazepam • Flutoprazepam • Fosazepam • Gidazepam • Halazepam • Iclazepam • Lopirazepam • Lorazepam • Lormetazepam • Meclonazepam • Medazepam • Menitrazepam • Metaclazepam • Motrazepam • Nimetazepam • Nitrazepam • Nitrazepate • Nordazepam • Nortetrazepam • Oxazepam • Phenazepam • Pinazepam • Pivoxazepam • Prazepam • Proflazepam • Quazepam • QH-II-66 • Reclazepam • Sulazepam • Temazepam • Tetrazepam • Tolufazepam • Tuclazepam • Uldazepam
Psycholeptics: anxiolytics (N05B)
|Benzodiazepine||Diazepam - Chlordiazepoxide - Medazepam - Oxazepam - Potassium clorazepate - Lorazepam - Adinazolam - Bromazepam - Clobazam - Ketazolam - Prazepam - Alprazolam - Halazepam - Pinazepam - Camazepam - Nordazepam - Fludiazepam - Ethyl loflazepate - Etizolam - Clotiazepam - Cloxazolam - Tofisopam|
|Diphenylmethane||Hydroxyzine - Captodiame|
|Carbamates||Meprobamate - Emylcamate - Mebutamate|
|Azaspirodecanedione (serotonin receptor agonist)||Buspirone - Gepirone - Tandospirone|
|Other||Mephenoxalone - Gedocarnil - Etifoxine|