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A parasympathomimetic is a drug or poison that acts by stimulating or mimicking the parasympathetic nervous system (PNS). These chemicals are also called cholinomimetic drugs or cholinergics because acetylcholine (ACh) is the neurotransmitter used by the PNS. Chemicals in this family can act by either directly stimulating the nicotinic or muscarinic receptors, or they can act indirectly by inhibiting cholinesterase, promoting acetylcholine release, or other mechanisms.
Some Chemical weapons such as sarin or VX, non-lethal riot control agents such as tear gas, and insecticides such as diazinon fall into this category.
Contents
Pharmaceuticals[edit | edit source]
Direct-acting[edit | edit source]
These act by stimulating the nicotinic or muscarinic receptors.
- Choline esters
- Acetylcholine (all acetylcholine receptors)
- Bethanechol (M3 receptors)
- Carbachol (all muscarinic receptors and some nicotinic receptors)
- Methacholine (all muscarinic receptors)
- Plant alkaloids
Indirect-acting[edit | edit source]
Indirect acting parasympathomimetic drugs may be either reversible cholinesterase inhibitors, irreversible cholinesterase inhibitors or drugs that promote ACh release or Anti-adrenergic. The latter inhibits the antagonistic system, the sympathetic nervous system.
- Reversible cholinesterase inhibitors
- Irreversible cholinesterase inhibitors
- ACh release promoters
- Anti-adrenergics
- clonidine (α-receptor agonist, α2 > α1, giving negative feedback)
- propranolol (β2 antagonist)
- atenolol (β1 antagonist)
- prazosin (α1 antagonist)
- methyldopa (α2 agonist giving negative feedback)
requiring classification[edit | edit source]
See also[edit | edit source]
- Analeptic drugs
- Cholinergic blocking drugs
- Cholinergic nerves
- Cholinesterase inhibitors
- Parasympathetic nervous system
References[edit | edit source]
See also[edit | edit source]
External links[edit | edit source]
Parasympathomimetics (N07A) | |
|---|---|
| Anticholinesterases |
Stigmine (Neostigmine, Pyridostigmine, Distigmine) - Ambenonium |
| Choline esters | |
| Other parasympathomimetics | |
Ophthalmologicals: antiglaucoma preparations and miotics (S01E) | |
|---|---|
| Sympathomimetics |
Apraclonidine • Brimonidine • Clonidine • Dipivefrine • Epinephrine |
| Parasympathomimetics |
Aceclidine • Acetylcholine • Carbachol • Demecarium • Echothiophate • Stigmine (Fluostigmine, Neostigmine, Physostigmine) • Paraoxon • Pilocarpine |
| Carbonic anhydrase inhibitors |
Acetazolamide • Brinzolamide • Diclofenamide • Dorzolamide • Methazolamide |
| Beta blocking agents |
Befunolol • Betaxolol • Carteolol • Levobunolol • Metipranolol • Timolol |
| Prostaglandin analogues | |
| Other agents | |
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