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Bursting is a rapid signaling mode in neurons whereby clusters of two or more action potentials are emitted as a single signaling event. Burst mode is thought to be useful for signaling important events and routing information in the brain. In general, there are two types of bursting:

  1. Input-driven bursting, where strong excitatory inputs produce a rapid activation and burst of action potentials
  2. Intrinsic bursting, where voltage-gated ion channels intrinsic to the neuron convert brief suprathreshold inputs into long-lasting bursts of action potential output.

The subiculum is an example of a brain region where the rapid transition between bursting and single-spiking is important for routing information out of the hippocampus.

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