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Adrenergic, beta-1-, receptor
External IDs OMIM: 109630 MGI87937 Homologene20171
RNA expression pattern


More reference expression data

Human Mouse Entrez 153 11554 Ensembl ENSG00000043591 ENSMUSG00000035283 Uniprot P08588 Q9CRR2 Refseq NM_000684 (mRNA)
NP_000675 (protein)
NM_007419 (mRNA)
NP_031445 (protein)
Location Chr 10: 115.79 - 115.8 Mb Chr 19: 56.78 - 56.78 Mb
Pubmed search [1] [2]

The beta-1 adrenergic receptor1 adrenoreceptor), also known as ADRB1, is an beta-adrenergic receptor, and also denotes the human gene encoding it.[1]

Receptor[edit | edit source]

Actions[edit | edit source]

Actions of the β1 receptor include:

Agonists[edit | edit source]

isoprenaline has higher affinity for β1 than noradrenaline, which, in turn, bind with higher affinity than adrenaline. Selective agonists to the beta-1 receptor are:

Antagonists[edit | edit source]

(Beta blockers) β1-selective ones are:

Mechanism[edit | edit source]

Gs renders adenylate cyclase activated, resulting in increase of cAMP.

Gene[edit | edit source]

Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure.[1]

See also[edit | edit source]

References[edit | edit source]

  1. 1.0 1.1 Entrez Gene: ADRB1 adrenergic, beta-1-, receptor.
  2. 2.0 2.1 2.2 2.3 2.4 Rang, H. P. (2003). Pharmacology, Edinburgh: Churchill Livingstone. Page 163
  3. 3.0 3.1 3.2 3.3 3.4 Fitzpatrick, David; Purves, Dale; Augustine, George (2004). "Table 20:2" Neuroscience, Third Edition, Sunderland, Mass: Sinauer.
  4. Bisoprolol MedlinePlus

Further reading[edit | edit source]

  • Frielle T, Kobilka B, Lefkowitz RJ, Caron MG (1989). Human beta 1- and beta 2-adrenergic receptors: structurally and functionally related receptors derived from distinct genes.. Trends Neurosci. 11 (7): 321-4.
  • Muszkat M (2007). Interethnic differences in drug response: the contribution of genetic variability in beta adrenergic receptor and cytochrome P4502C9.. Clin. Pharmacol. Ther. 82 (2): 215-8.
  • Yang-Feng TL, Xue FY, Zhong WW, et al. (1990). Chromosomal organization of adrenergic receptor genes.. Proc. Natl. Acad. Sci. U.S.A. 87 (4): 1516-20.
  • Forse RA, Leibel R, Gagner M (1989). The effect of Escherichia coli endotoxin on the adrenergic control of lipolysis in the human adipocyte.. J. Surg. Res. 46 (1): 41-8.
  • Frielle T, Collins S, Daniel KW, et al. (1987). Cloning of the cDNA for the human beta 1-adrenergic receptor.. Proc. Natl. Acad. Sci. U.S.A. 84 (22): 7920-4.
  • Stiles GL, Strasser RH, Lavin TN, et al. (1983). The cardiac beta-adrenergic receptor. Structural similarities of beta 1 and beta 2 receptor subtypes demonstrated by photoaffinity labeling.. J. Biol. Chem. 258 (13): 8443-9.
  • Hoehe MR, Otterud B, Hsieh WT, et al. (1995). Genetic mapping of adrenergic receptor genes in humans.. J. Mol. Med. 73 (6): 299-306.
  • Elies R, Ferrari I, Wallukat G, et al. (1996). Structural and functional analysis of the B cell epitopes recognized by anti-receptor autoantibodies in patients with Chagas' disease.. J. Immunol. 157 (9): 4203-11.
  • Oldenhof J, Vickery R, Anafi M, et al. (1998). SH3 binding domains in the dopamine D4 receptor.. Biochemistry 37 (45): 15726-36.
  • Mason DA, Moore JD, Green SA, Liggett SB (1999). A gain-of-function polymorphism in a G-protein coupling domain of the human beta1-adrenergic receptor.. J. Biol. Chem. 274 (18): 12670-4.
  • Moore JD, Mason DA, Green SA, et al. (1999). Racial differences in the frequencies of cardiac beta(1)-adrenergic receptor polymorphisms: analysis of c145A>G and c1165G>C.. Hum. Mutat. 14 (3): 271.
  • Tang Y, Hu LA, Miller WE, et al. (1999). Identification of the endophilins (SH3p4/p8/p13) as novel binding partners for the beta1-adrenergic receptor.. Proc. Natl. Acad. Sci. U.S.A. 96 (22): 12559-64.
  • Podlowski S, Wenzel K, Luther HP, et al. (2000). Beta1-adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy?. J. Mol. Med. 78 (2): 87-93.
  • Shiina T, Kawasaki A, Nagao T, Kurose H (2000). Interaction with beta-arrestin determines the difference in internalization behavor between beta1- and beta2-adrenergic receptors.. J. Biol. Chem. 275 (37): 29082-90.
  • Hu LA, Tang Y, Miller WE, et al. (2001). beta 1-adrenergic receptor association with PSD-95. Inhibition of receptor internalization and facilitation of beta 1-adrenergic receptor interaction with N-methyl-D-aspartate receptors.. J. Biol. Chem. 275 (49): 38659-66.
  • Börjesson M, Magnusson Y, Hjalmarson A, Andersson B (2001). A novel polymorphism in the gene coding for the beta(1)-adrenergic receptor associated with survival in patients with heart failure.. Eur. Heart J. 21 (22): 1853-8.
  • Xu J, Paquet M, Lau AG, et al. (2001). beta 1-adrenergic receptor association with the synaptic scaffolding protein membrane-associated guanylate kinase inverted-2 (MAGI-2). Differential regulation of receptor internalization by MAGI-2 and PSD-95.. J. Biol. Chem. 276 (44): 41310-7.
  • Hu LA, Chen W, Premont RT, et al. (2002). G protein-coupled receptor kinase 5 regulates beta 1-adrenergic receptor association with PSD-95.. J. Biol. Chem. 277 (2): 1607-13.
  • Ranade K, Jorgenson E, Sheu WH, et al. (2002). A polymorphism in the beta1 adrenergic receptor is associated with resting heart rate.. Am. J. Hum. Genet. 70 (4): 935-42.

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