Changes: Axotomy

Axotomy
	Intervention
	Script error: No such module "InfoboxImage".
MeSH	D019771

Latest revision as of 13:44, 3 October 2013

Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)

An axotomy is the cutting or otherwise severing of an axon. Derived from axo- (=axon) and -tomy (=surgery). This type of denervation is often used in experimental studies on neuronal physiology and neuronal death or survival as a method to better understand nervous system diseases.^[1]

Axotomy may cause neuronal cell death, especially in embryonic or neonatal animals, as this is the period in which neurons are dependent on their targets for the supply of survival factors. In mature animals, where survival factors are derived locally or via autocrine loops, axotomy of peripheral neurons and motoneurons can lead to a robust regenerative response without any neuronal death. In both cases, autophagy is observed to markedly increase. Autophagy could either clear the way for neuronal degeneration or it could be a medium for cell destruction.^[2]

References

↑ "Online Medical Dictionary"
↑ Rubinsztein DC et al. (2005) Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair. Autophagy 1(1):11-22. PMID 16874045

|}

This cell biology article is a stub. You can help Wikipedia by expanding it.

[MedDictionary-1] "Online Medical Dictionary"

[Rub-2] Rubinsztein DC et al. (2005) Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair. Autophagy 1(1):11-22. PMID 16874045

[1]

[2]

@@ Line 1: / Line 1: @@
-{{BiopSy}}
+{{BioPsy}}
 {{Interventions infobox |
   Name        = {{PAGENAME}} |
@@ Line 13: / Line 13: @@
 An '''axotomy''' is the cutting or otherwise severing of an [[axon]]. Derived from axo- (=axon) and -tomy (=surgery). This type of [[denervation]] is often used in experimental studies on [[neuron]]al physiology and neuronal death or survival as a method to better understand [[ICD-10 Chapter VI: Diseases of the nervous system|nervous system diseases]].<ref name="MedDictionary">[http://cancerweb.ncl.ac.uk/cgi-bin/omd?axotomy "Online Medical Dictionary"]</ref>
-Axotomy may cause neuronal cell death, especially in [[embryo]]nic or [[neonatal]] animals, as this is the period in which [[neuron]]s are dependent on their targets for the supply of survival factors. In mature animals, where survival factors are derived locally or via [[autocrine]] loops, axotomy of [[peripheral]] neurons and [[motor neuron|motoneurons]] can lead to a robust regenerative response without any neuronal death. In both cases, [[autophagy]] is observed to markedly increase. Autophagy could either clear the way for neuronal degeneration or it could be a medium for cell destruction.<ref name="Rub">Rubinsztein DC et al. (2005) Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair. Autophagy 1(1):11-22. PMID 16874045</ref>
+Axotomy may cause neuronal cell death, especially in [[embryo]]nic or [[neonatal]] animals, as this is the period in which [[neuron]]s are dependent on their targets for the supply of survival factors. In mature animals, where survival factors are derived locally or via [[autocrine]] loops, axotomy of [[peripheral neurons]] and [[motor neuron|motoneurons]] can lead to a robust regenerative response without any neuronal death. In both cases, [[autophagy]] is observed to markedly increase. Autophagy could either clear the way for neuronal degeneration or it could be a medium for cell destruction.<ref name="Rub">Rubinsztein DC et al. (2005) Autophagy and Its Possible Roles in Nervous System Diseases, Damage and Repair. Autophagy 1(1):11-22. PMID 16874045</ref>
 ==See also==

Axotomy
Intervention
Script error: No such module "InfoboxImage".
MeSH	D019771