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Arginine vasopressin receptor 1A
Symbol(s) AVPR1A; AVPR1
External IDs OMIM: 600821 MGI1859216 Homologene568
RNA expression pattern




More reference expression data

Human Mouse Entrez 552 54140 Ensembl ENSG00000166148 ENSMUSG00000020123 Uniprot P37288 Q3U1H9 Refseq NM_000706 (mRNA)
NP_000697 (protein)
NM_016847 (mRNA)
NP_058543 (protein)
Location Chr 12: 61.83 - 61.83 Mb Chr 10: 121.85 - 121.86 Mb
Pubmed search [1] [2]

Arginine vasopressin receptor 1A (AVPR1A) is a protein that acts as receptor for arginine vasopressin.[1] AVPR1A belongs to the subfamily of G-protein coupled receptors.

Its activity is mediated by G proteins which stimulate a phosphatidylinositol-calcium second messenger system.

The activity / genetic variants of the AVPR1 gene might be related to generosity and altruistic behavior.[2]

See also[]


  1. Thibonnier M, Auzan C, Madhun Z, Wilkins P, Berti-Mattera L, Clauser E (1994). Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor. J. Biol. Chem. 269 (5): 3304–10.
  2. Knafo A, Israel S, Darvasi A, Bachner-Melman R, Uzefovsky F, Cohen L, Feldman E, Lerer E, Laiba E, Raz Y, Nemanov L, Gritsenko I, Dina C, Agam G, Dean B, Bornstein G, Ebstein RP (2007). Individual differences in allocation of funds in the dictator game associated with length of the arginine vasopressin 1a receptor RS3 promoter region and correlation between RS3 length and hippocampal mRNA. Genes Brain Behav.

Further reading[]

  • Thibonnier M, Coles P, Thibonnier A, Shoham M (2002). Molecular pharmacology and modeling of vasopressin receptors.. Prog. Brain Res. 139: 179-96.
  • Cross SH, Charlton JA, Nan X, Bird AP (1994). Purification of CpG islands using a methylated DNA binding column.. Nat. Genet. 6 (3): 236-44.
  • Hirasawa A, Shibata K, Kotosai K, Tsujimoto G (1994). Cloning, functional expression and tissue distribution of human cDNA for the vascular-type vasopressin receptor.. Biochem. Biophys. Res. Commun. 203 (1): 72-9.
  • Thibonnier M, Auzan C, Madhun Z, et al. (1994). Molecular cloning, sequencing, and functional expression of a cDNA encoding the human V1a vasopressin receptor.. J. Biol. Chem. 269 (5): 3304-10.
  • Young WS, Kovács K, Lolait SJ (1993). The diurnal rhythm in vasopressin V1a receptor expression in the suprachiasmatic nucleus is not dependent on vasopressin.. Endocrinology 133 (2): 585-90.
  • Thibonnier M, Graves MK, Wagner MS, et al. (1997). Structure, sequence, expression, and chromosomal localization of the human V1a vasopressin receptor gene.. Genomics 31 (3): 327-34.
  • North WG, Fay MJ, Longo K, Du J (1998). Functional vasopressin V1 type receptors are present in variant as well as classical forms of small-cell carcinoma.. Peptides 18 (7): 985-93.
  • North WG, Fay MJ, Longo KA, Du J (1998). Expression of all known vasopressin receptor subtypes by small cell tumors implies a multifaceted role for this neuropeptide.. Cancer Res. 58 (9): 1866-71.
  • North WG, Fay MJ, Du J (1999). MCF-7 breast cancer cells express normal forms of all vasopressin receptors plus an abnormal V2R.. Peptides 20 (7): 837-42.
  • Tahara A, Tsukada J, Ishii N, et al. (1999). Comparison of vasopressin binding sites in human uterine and vascular smooth muscle cells.. Eur. J. Pharmacol. 378 (1): 137-42.
  • Thibonnier M, Graves MK, Wagner MS, et al. (2000). Study of V(1)-vascular vasopressin receptor gene microsatellite polymorphisms in human essential hypertension.. J. Mol. Cell. Cardiol. 32 (4): 557-64.
  • Berrada K, Plesnicher CL, Luo X, Thibonnier M (2000). Dynamic interaction of human vasopressin/oxytocin receptor subtypes with G protein-coupled receptor kinases and protein kinase C after agonist stimulation.. J. Biol. Chem. 275 (35): 27229-37.
  • Kim SJ, Young LJ, Gonen D, et al. (2002). Transmission disequilibrium testing of arginine vasopressin receptor 1A (AVPR1A) polymorphisms in autism.. Mol. Psychiatry 7 (5): 503-7.
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903.
  • Tahtaoui C, Balestre MN, Klotz P, et al. (2003). Identification of the binding sites of the SR49059 nonpeptide antagonist into the V1a vasopressin receptor using sulfydryl-reactive ligands and cysteine mutants as chemical sensors.. J. Biol. Chem. 278 (41): 40010-9.
  • Hawtin SR, Wesley VJ, Simms J, et al. (2004). An arginyl in the N-terminus of the V1a vasopressin receptor is part of the conformational switch controlling activation by agonist.. Eur. J. Biochem. 270 (23): 4681-8.
  • Terrillon S, Barberis C, Bouvier M (2004). Heterodimerization of V1a and V2 vasopressin receptors determines the interaction with beta-arrestin and their trafficking patterns.. Proc. Natl. Acad. Sci. U.S.A. 101 (6): 1548-53.
  • Wassink TH, Piven J, Vieland VJ, et al. (2005). Examination of AVPR1a as an autism susceptibility gene.. Mol. Psychiatry 9 (10): 968-72.
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).. Genome Res. 14 (10B): 2121-7.

External links[]

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