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Angiotensin I converting enzyme
Symbol(s): ACE CD143, CD143
Locus: 17 q23
EC number 3.4.15.1
EntrezGene 1636
OMIM 106180
RefSeq NM_000789
UniProt P12821

Angiotensin I converting enzyme (ACE, EC 3.4.15.1) is an exopeptidase.

Functions[edit | edit source]

It has two primary functions:

These two actions of ACE make it an ideal target in the treatment of conditions such as high blood pressure, heart failure, diabetic nephropathy and type 2 diabetes mellitus. Inhibition of ACE (by ACE inhibitors) results in decreased formation of Angiotensin II (a far more potent vasoconstrictor than Angiotensin I) and decreased inactivation of bradykinin.

Synonyms[edit | edit source]

ACE is also known as:

Genetics[edit | edit source]

The ACE gene, ACE, encodes 2 isozymes. The somatic isozyme is expressed in many tissues, including vascular endothelial cells, epithelial kidney cells, and testicular Leydig cells, whereas the germinal is expressed only in sperm.

See also[edit | edit source]

References[edit | edit source]

External links[edit | edit source]



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