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Main article: Apraxia

Akinesia is the inability to initiate movement, due to problems with selecting and activating motor programs in the brain. It is a common consequence of Parkinson's disease caused by dopamine loss in the direct pathway of movement. There is a general quietening of spontaneous motor activity and production of everyday gestures.

The word "akinetic" comes from the prefix "a-" meaning "without" + the Greek word "kinesis" meaning motion = without motion.

For example, a person in coma is akinetic. For another example, akinetic mutism is a condition in which a person is both mute and akinetic. A textbook on clinical neurology observes that a person with akinetic mutism has "sleep-waking cycles but, when apparently awake, with eyes open, lies mute, immobile and unresponsive." some dictionaries describe it as loss of normal muscle tone.

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The impairments can arise from lesions in the motor cortex.

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