Assessment |
Biopsychology |
Comparative |
Cognitive |
Developmental |
Language |
Individual differences |
Personality |
Philosophy |
Social |
Methods |
Statistics |
Clinical |
Educational |
Industrial |
Professional items |
World psychology |
Biological: Behavioural genetics · Evolutionary psychology · Neuroanatomy · Neurochemistry · Neuroendocrinology · Neuroscience · Psychoneuroimmunology · Physiological Psychology · Psychopharmacology (Index, Outline)
Template:Chembox OtherNames
| style="background: #F8EABA; text-align: center;" colspan="2" | 3-Iodothyronamine |
|---|---|
| File:3-Iodothyronamine.png | |
4-[4-(2-Amino-ethyl)-2-iodo-phenoxy]-phenol | |
| Identifiers | |
| CAS number | 712349-95-6 |
| SMILES | OC1=CC=C(OC2=C(I)C=C(CCN)C=C2)C=C1 |
| Properties | |
| Molecular formula | C14H14INO2 |
| Molar mass | 355.17 g/mol |
| Hazards | |
| style="background: #F8EABA; text-align: center;" colspan="2" | Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
3-iodothyronamine (T1AM) is an endogenous thyronamine. T1AM is a high-affinity ligand for the trace amine-associated receptor TAAR1 (TAR1, TA1), a G protein-coupled receptor.[1]
[2] In rodents, T1AM causes a rapid drop in body temperature when injected.
T1AM may be part of a signaling pathway to modulate cardiac function as the compound can induce negative inotropic effects and decrease cardiac output.[3]
See also[]
External links[]
References[]
- ↑ Scanlan T, Suchland K, Hart M, Chiellini G, Huang Y, Kruzich P, Frascarelli S, Crossley D, Bunzow J, Ronca-Testoni S, Lin E, Hatton D, Zucchi R, Grandy D (2004). 3-Iodothyronamine is an endogenous and rapid-acting derivative of thyroid hormone. Nat. Med. 10 (6): 638-42.
- ↑ Hart M, Suchland K, Miyakawa M, Bunzow J, Grandy D, Scanlan T (2006). Trace amine-associated receptor agonists: synthesis and evaluation of thyronamines and related analogues. J. Med. Chem. 49 (3): 1101-12.
- ↑ Chiellini G, Frascarelli S, Ghelardoni S, Carnicelli V, Tobias SC, Debarber A, Brogioni S, Ronca-Testoni S, Cerbai E, Grandy DK, Scanlan TS, Zucchi R. (2007). Cardiac effects of 3-iodothyronamine: a new aminergic system modulating cardiac function.
| This page uses Creative Commons Licensed content from Wikipedia (view authors). |