Dactylysin

Dactylysin (, peptide hormone inactivating endopeptidase, PHIE) is an enzyme. This enzyme catalyses the following chemical reaction


 * Hydrolysis of peptides of at least six residues, with bulky hydrophobic residues in the P1' position. Shows a preference for hydrophobic doublets such as -Phe-Phe- and -Phe-Leu- in somatostatin-(1-14)-peptide and dynorphin A-(1-6)-peptide, respectively

This endopeptidase in the skin of the amphibian, Xenopus laevis.