Depression - Neuroanatomy

In the 1930s, it was realized that stimulating the surgically exposed brain in specific areas could bring about reported mood and emotional changes. At the same time, surgical destruction of these regions could alter negative mood. The results indicated that the orbitofrontal cortex and the frontal, temporal, and basal ganglia played important roles in mood regulation.

The development of additonal techniques have allowed for this picture to be further developed