Cyclopyrrolones

Cyclopyrrolones are a family of hypnotic and anxiolytic nonbenzodiazepine drugs with similar pharmacological profiles to the benzodiazepine derivatives.

Although cyclopyrrolones are chemically unrelated to benzodiazepines, they function via the benzodiazepine receptor/GABA neurotransmitter. The best known cyclopyrrolone derivatives are zopiclone (Imovane) and its enantiomer eszopiclone (Lunesta), which are used to treat insomnia, and have a known potential for abuse. Other cyclopyrrolone derivatives include suriclone, pagoclone, pazinaclone and suproclone.


 * Cyclopyrrolones
 * eszopiclone - hypnotic (Lunesta)
 * zopiclone - hypnotic (Imovane)
 * pagoclone - anxiolytic
 * suriclone - anxiolytic
 * pazinaclone - anxiolytic
 * suproclone - anxiolytic