Lofepramine

Lofepramine (trademarked Gamanil) is a third generation tricyclic antidepressant used in the treatment of depressive disorders. It has both antidepressant and anxiolytic properties. Lofepramine is metabolized in vivo into desipramine; hence its pharmacological profile is extremely similar.

Indications
In the United Kingdom, lofepramine is licensed for the treatment of depression.

Availability
In the United Kingdom, lofepramine is marketed generically (as the hydrochloride salt) in the form of 70mg tablets.

Dosage
140-210mg daily in divided doses.