Intraperitoneal injections

Intraperitoneal injection or IP injection is the injection of a substance into the peritoneum (body cavity). IP injection is more often applied to animals than humans. It is generally preferred when large amounts of blood replacement fluids are needed, or when low blood pressure or other problems prevent the use of a suitable blood vessel for intravenous injection.

In animals, IP injection is predominantly used in veterinary medicine and animal testing for the administration of systemic drugs and fluids due to the ease of administration compared with other parenteral methods.

In humans, the method is widely used to administer chemotherapy drugs to treat some cancers, particularly ovarian cancer. This specific use has been recommended, controversially, as a standard of care.

Papers
Ball, G. G. (1964). T-maze learning in the thirsty rat with intraperitoneal injections of water as reinforcement. Dissertation Abstracts, 25(1), 637-638. Canova, A., & Geary, N. (1991). Intraperitoneal injections of nanogram CCK-8 doses inhibit feeding in rats. Appetite, 17(3), 221-227. Erspamer, R., & Crow, L. T. (1972). A depression of ethanol consumption in rats as a result of intraperitoneal injections of pyrazole. Psychonomic Science, 26(1), 29-30. Ferguson, D. C. (1962). Precision timing behavior in cebus apella as a function of intraperitoneal injections of normal, stressed normal and catatonic schizophrenic serum and plasma. Dissertation Abstracts, 23(1). Fried, P. A. (1976). Cross-tolerance between inhaled cannabis and intraperitoneal injections of D-sup-9-THC. Pharmacology, Biochemistry and Behavior, 4(6), 635-638. Grabenstatter, H. L., Clark, S., & Dudek, F. E. (2007). Anticonvulsant effects of carbamazepine on spontaneous seizures in rats with kainate-induced epilepsy: Comparison of intraperitoneal injections with drug-in-food protocols. Epilepsia, 48(12), 2287-2295. Hymowitz, N., & et al. (1985). Effect of repeated intraperitoneal injections of soman on schedule-controlled behavior in the rat. Psychopharmacology, 86(4), 404-408. Jacquet, Y. F. (1980). Different behavioral effects following intracerebral, intracerebroventricular or intraperitoneal injections of naloxone in the rat. Behavioural Brain Research, 1(6), 543-546. Moynihan, J. A., Koota, D., Brenner, G., Cohen, N., & et al. (1989). Repeated intraperitoneal injections of saline attenuate the antibody response to a subsequent intraperitoneal injection of antigen. Brain, Behavior, and Immunity, 3(1), 90-96. O'Callaghan, M. J., Croft, A. P., & Little, H. J. (2002). Effects of intraperitoneal injections of saline on the alcohol and sucrose consumption of C57/BL10 mice. Psychopharmacology, 160(2), 206-212. Rauch, T. M., Gallego, E., & Welch, D. I. (1988). Retention of a spatial task after intraperitoneal, subcutaneous or intravenous injections of equal doses of atropine. Life Sciences, 43(23), 1913-1920. Richy, S., Burlet, A., Max, J.-P., Burlet, C., & Beck, B. (2000). Effect of chronic intraperitoneal injections of leptin on hypothalamic neurotensin content and food intake. Brain Research, 862(1-2), 276-279. Stamoutsos, B. A., Carpenter, R. G., Grossman, L., & Grossman, S. P. (1979). Impaired feeding responses to intragastric, intraperitoneal, and subcutaneous injections of 2-deoxy-D-glucose in rats with zona incerta lesions. Physiology & Behavior, 23(4), 771-776.

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