Paramedian pontine reticular formation

The paramedian pontine reticular formation, or PPRF, is a brain region, without clearly defined borders, in the center of the pons. It is involved in the coordination of eye movements, particularly saccades.

Inputs, outputs, functions
The PPRF is located anterior and lateral to the medial longitudinal fasciculus (MLF). It receives input from the superior colliculus via the predorsal bundle and from the frontal eye fields via frontopontine fibers. The rostral PPRF probably coordinates horizontal saccades; the caudal PPRF may be the generator of both horizontal and vertical saccades. In particular, activity of the excitatory burst neurons (EBNs) in the PPRF generates the "pulse" movement that initiates a saccade. In the case of horizontal saccades the "pulse" information is conveyed via axonal fibers to the abducens nucleus, initiating lateral eye movements. The angular velocity of the eye during horizontal saccade ranges from 100 to 700 degrees per second. Larger saccades have faster pulses; the PPRF is involved in this determination.

Lesions
Unilateral lesions of the PPRF produce characteristic findings:
 * Loss of horizontal saccades directed towards the side of the lesion, no matter the current position of gaze
 * Contralateral gaze deviation (acute lesions, such as early stroke, only)
 * Gaze-evoked lateral nystagmus on looking away from the side of the lesion
 * Bilateral lesions produce horizontal gaze palsy and slowing of vertical saccades