Thyrotropin-releasing hormone

Thyrotropin-releasing hormone (TRH) is a tripeptide hormone that stimulates the release of TSH and prolactin by the anterior pituitary. TRH is produced by the hypothalamus and travels across the median eminence to the pituitary via the pituitary portal system.

In addition to the brain, TRH can also be detected in other areas of the body including the gastrointestinal system and pancreatic islets. Medical preparations of TRH are used in diagnostic tests of thyroid disorders and in acromegaly.

The sequence of TRH was first determined and the hormone synthesized by Roger Guillemin and Andrew V. Schally in 1969. Its molecular weight is 359.5 Da and its structure is:

(pyro)Glu-His-Pro-NH2

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Hormona liberadora de tirotrofina Hormone thyréotrope

Тиролиберин