Lipid soluble hormones

Lipid soluble hormones are able to pass through the membrane of target cell’s. They bind to receptors inside the cell and this activates the hormone, which then binds to a portion of DNA inside the cell’s nucleus. Binding to the DNA causes genes to turn enzyme activity on or off, which alters the activity of the target cell.

Steroid hormones are lipid soluble.

Lipid-soluble hormone receptors
Steroid hormone receptors and related receptors are generally soluble proteins that function through gene activation. Their response elements are DNA sequences (promoters) that are bound by the complex of the steroid bound to its receptor. The receptors themselves are zinc-finger proteins. These receptors include those for glucocorticoids, estrogens, androgens, thyroid hormone (T3), calcitriol (the active form of vitamin D), and the retinoids (vitamin A).