Nicotinic antagonist

A nicotinic antagonist is a type of anticholinergic which inhibits the action at nicotinic acetylcholine receptors. These compounds are mainly used for peripheral muscle paralysis in surgery, but some centrally acting compounds such as mecamylamine and 18-methoxycoronaridine block nicotinic acetylcholine receptors in the brain and can be used for treating drug addiction.


 * Ganglionic blocking agents
 * Hexamethonium
 * Mecamylamine
 * Trimethaphan


 * Nondepolarizing neuromuscular blocking agents
 * Atracurium
 * Doxacurium
 * Mivacurium
 * Pancuronium
 * Tubocurarine
 * Vecuronium


 * Depolarizing neuromuscular blocking agents
 * Succinylcholine


 * Centrally acting nicotinic antagonists
 * 18-Methoxycoronaridine - selective α3β4 nicotinic antagonist acting in the brain