Dorsolateral prefrontal cortex

The dorsolateral prefrontal cortex (DL-PFC or DLPFC) is the last area (45th) to develop (myelinate) in the human cerebrum. A more restricted definition of this area describes it as roughly equivalent to Brodmann's areas 9 and 46, according to a broader definition DL-PFC consists of the lateral portions of Brodmann’s areas 9 – 12, of areas 45, 46, and the superior part of area 47. These regions mainly receive their blood supply from the middle cerebral artery. With respect to neurotransmitter systems, there is evidence that dopamine plays a particularly important role in DL-PFC.

DL-PFC is connected to the orbitofrontal cortex, and to a variety of brain areas, which include the thalamus, parts of the basal ganglia (the dorsal caudate nucleus), the hippocampus, and primary and secondary association areas of neocortex, including posterior temporal, parietal, and occipital areas.

Function
DL-PFC serves as the highest cortical area responsible for motor planning, organization, and regulation. It plays an important role in the integration of sensory and mnemonic information and the regulation of intellectual function and action. It is also involved in working memory. However, DL-PFC is not exclusively responsible for the executive functions. All complex mental activity require the additional cortical and subcortical circuits that DL-PFC is connected with.

The stroke syndrome which results from damage to the DLPFC is called "disexecutive syndrome". Functional studies demonstrate both executive function as well as Working Memory.