Metirosine

Metirosine (α-Methyltyrosine, Metyrosine, AMPT) is an antihypertensive drug. It inhibits the enzyme tyrosine hydroxylase and, therefore, catecholamine synthesis, which consequently depletes the levels of the catecholamines dopamine, adrenaline and noradrenaline in the body.

Clinical use
Metirosine has been used in the treatment of phaeochromocytoma. It is contra-indicated for the treatment of essential hypertension.

However it is now rarely used in medicine, and its main use is in scientific research, to investigate the effects of catecholamine depletion on behaviour.