Paternal age effect

The paternal age effect describes the influence that a father's age has on the chances of conferring a genetic defect to his offspring. Generally, older men have a greater probability of fathering children with a genetic defect than younger men do. This is seen as likely due to genetic copying errors which may increase in number after repeated spermatogenesis cycles over a man's lifetime.

Disorders correlated with paternal age
Achondroplasia (dwarfism); craniofacial disorders such as Apert syndrome and Crouzon Syndrome; mental retardation of unknown etiologies; autism; bipolar disorder; and 25% of schizophrenia cases are correlated with advanced paternal age.

Other disorders related to advanced paternal age are:
 * Wilms' tumor
 * Thanatophoric dysplasia
 * Retinitis pigmentosa
 * Osteogenesis imperfecta type IIA
 * Acrodysostosis
 * Fibrodysplasia ossificans progressiva
 * Aniridia
 * Bilateral retinoblastoma
 * Multiple exostoses
 * Marfan Syndrome
 * Lesch-Nyhan syndrome
 * Pfeiffer Syndrome
 * Wardenburg Syndrome
 * Treacher-Collins Syndrome
 * Soto’s basal cell nevus
 * Cleidocranial dysostosis
 * Polyposis coli
 * Oculodentodigital syndrome
 * Costello syndrome
 * Progeria
 * Recklinghausen’s neurofibromatosis
 * Tuberous sclerosis
 * Polycystic kidney disease
 * Hemophilia A
 * Duchenne muscular dystrophy
 * Athetoid Cerebral Palsy
 * Dystonic Cerebral Palsy
 * Congenital Hemiplegia
 * Down syndrome
 * Bipolar disorder