Zona fasciculata

Cells of the zona fasciculataare part of the adrenal cortex and sit directly beneath the zona glomerulosa and are organized in bundles (or fascicles).

The zona chiefly produces glucocorticoids (eg, cortisol).

In addition to glucocorticoid production, the fasciculata is a secondary source of androgens such as testosterone, dihydrotestosterone (DHT), androstenedione, and dehydroepiandrosterone (DHEA). These enhance muscle mass, stimulate cell growth, and aid in the development of the secondary sex characteristics.