Catechol-O-methyl transferase

Catechol-O-methyl transferase (COMT) is an enzyme first discovered by biochemist Julius Axelrod. COMT is the name given to the gene which codes for this enzyme. The O in the name stands for oxygen, not for ortho.

Catechol-O-methyl transferase is involved in the breakdown of the catecholamine neurotransmitters, dopamine, epinephrine and norepinephrine. The enzyme introduces a methyl group to the catecholamine which is donated by S-adenosyl methionine (SAM). Any compound having a catechol structure, like catecholestrogens and catechol-containing flavonoids are substrates of COMT. L-dopa, a precursor of catecholamines, is an important substrate of COMT. COMT inhibitors, like entacapone saves L-dopa from COMT and prolongs the action of L-dopa. Entacapone is a widely used adjuct drug of L-dopa therapy. When given with an inhibitor of dopa decarboxylase (carbidopa or benserazide), L-dopa is optimally saved. This "triple therapy" is becoming a standard in the treatment of Parkinson's disease.

A functional polymorphism (a common normal variant) of the gene for catechol-O-methyl transferase has been shown to affect cognitive tasks broadly related to executive function, such as set shifting, response inhibition, abstract thought and the acquisition of rules or task structure.

The link between impairments in these sorts of cognitive tasks and the COMT gene is thought to be mediated by an effect on dopamine signalling in the frontal lobes.

Comparable effects on similar cognitive tasks, the frontal lobes and the neurotransmitter dopamine have also all been linked to schizophrenia. Unsurprisingly, an inherited variant of COMT is thought to be one of the genetic factors which may predispose someone to developing schizophrenia later in life, naturally or due to adolescent-onset cannabis use.

COMT inhibitors are found in green tea. Drinking green tea is, therefore, thought to provide a useful short-term boost to antidepressant medication by increasing the half life of extracellular noradrenaline and dopamine. Tea may also help reduce the risk of breast cancer.