Parathyroid hormone receptor

There are two known parathyroid hormone receptors in mammals termed PTH1R and PTH2R. These receptors are members of the 7 transmembrane G protein-coupled family of receptors.


 * parathyroid hormone receptor 1 (PTH1) is the classical PTH receptor, is expressed in high levels in bone and kidney and regulates calcium ion homeostasis through activation of adenylate cyclase and phospholipase C.


 * parathyroid hormone receptor 2 (PTH2) is expressed primarily in the central nervous system, pancreas, testis, and placenta.